Tropomyosin alpha-4 chain Antibodies

AND TPM4 ELISA kits, Tropomyosin alpha-4 chain Proteins

Many biological assays use antibodies to detect Tropomyosin alpha-4 chain, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tropomyosin alpha-4 chain in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tropomyosin alpha-4 chain antibodies...

We validate the specificity of these antibodies to Tropomyosin alpha-4 chain by testing them on tissues known to express TPM4 positively and negatively. Browse below to find the TPM4 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TPM4 Infographic by Boster Bio

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TPM4 (NM_003290) Human Recombinant Protein

$1062
Cat # PROTP67936
20 µg

TPM4 Overview

Facts about Tropomyosin alpha-4 chain.

TPM4 3D structure. Source: alphafold

Tropomyosin alpha-4 chain (TPM4)

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction.

Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity).

Gene Information

Human
Gene Name:	TPM4
Uniprot:	P67936
Entrez:	7171

Family

Belongs to:

tropomyosin family

Alternative Names

TM30p1; tropomyosin 4; tropomyosin alpha-4 chain; tropomyosin-4

Molecular Weight

Mass (kDA):
28.522 kDA

Genomic Context


Human

Location:	19p13.12-p13.11
Sequence:	19; NC_000019.10 (16067507..16103005)

Tissue Specificity

Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level).

Subcellular Localizations

Cytoplasm, cytoskeleton. Associates with F-actin stress fibers.

Diseases

Malignant Neoplasms
Neoplasms
Lymphoma
Diffuse Large B-cell Lymphoma
Ki-1+ Anaplastic Large Cell Lymphoma
Carcinoma
Malignant Neoplasm Of Lung
Lung Neoplasms
Anaplastic Lymphoma
Malignant Neoplasm Of Breast
Neoplasm Invasiveness
Anaplasia
Non-small Cell Lung Carcinoma

Malignant Paraganglionic Neoplasm
Chromosomal Translocation
Inflammation
Carcinogenesis
Inflammatory Myofibroblastic Tumor
Malignant Squamous Cell Neoplasm
Neoplasm Metastasis

Pathways

Localization
Pathogenesis
Cell Proliferation
Rna Splicing
Reverse Transcription
Dedifferentiation
Heart Development
Transport
Cell Activation
Cell Migration
Endothelial Cell Activation
Regulation Of Cytoskeleton
Lung Development

Muscle Contraction
Metaphase
Granulosa Cell Differentiation
Cytokinesis
Regeneration
Embryo Implantation
Cell Motility

PTMs

Phosphorylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TPM4

References

PMID: 3612796 by McLeod A.R., et al. Characterization of a cDNA defining a gene family encoding TM30p1, a human fibroblast tropomyosin.

PMID: 1836432 by Crabos M., et al. The calcium binding protein tropomyosin in human platelets and cardiac tissue: elevation in hypertensive cardiac hypertrophy.