This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
DNA topoisomerase 2-alpha Antibodies
AND TOP2A ELISA kits, DNA topoisomerase 2-alpha Proteins
Many biological assays use antibodies to detect DNA topoisomerase 2-alpha, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DNA topoisomerase 2-alpha in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DNA topoisomerase 2-alpha antibodies...
Previous: CBLIF
Next: TOP2B
TOP2A Infographic by Boster Bio
All TOP2A Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
IF, IHC, WB
$486
Cat # M00953
100ug/vial
Cat # M00953
100ug/vial
Human, Mouse, Rat
IP, IHC, WB
$370
Cat # M00953-1
100 μl
Cat # M00953-1
100 μl
Human
ELISA
$480
Cat # EKC1571
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1571
1 kit, containing one 96-well plate and all necessary reagents
Human
ELISA
$540
Cat # EKC2312
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2312
1 kit, containing two 96-well plates and all necessary reagents
Human
ELISA
$540
Cat # EKC2591
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2591
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2629
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2629
1 kit, containing two 96-well plates and all necessary reagents
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00953
100 μg/vial
Cat # A00953
100 μg/vial
Human, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A00953S1525
100ul
Cat # A00953S1525
100ul
Human
$960
Cat # LS007153
100 µg
Cat # LS007153
100 µg
TOP2A Overview
Facts about DNA topoisomerase 2-alpha.
DNA topoisomerase 2-alpha (TOP2A)
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | TOP2A |
| Uniprot: | P11388 |
| Entrez: | 7153 |
Family
| Belongs to: |
|---|
| type II topoisomerase family |
Alternative Names
DNA topoisomerase (ATP-hydrolyzing); DNA topoisomerase 2-alpha; DNA topoisomerase II, 170 kD; DNA topoisomerase II, alpha isozyme; EC 5.99.1.3; TOP2; TOP2A; TOP2DNA gyrase; topoisomerase (DNA) II alpha (170kD); topoisomerase (DNA) II alpha 170kDa; TP2A
Molecular Weight
Mass (kDA):
174.385 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.2 |
| Sequence: | 17; NC_000017.11 (40388525..40417902, complement) |
Subcellular Localizations
Cytoplasm. Nucleus, nucleoplasm. Generally located in the nucleoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Carcinoma
- Neoplasm Metastasis
- Adenocarcinoma
- Malignant Paraganglionic Neoplasm
- Leukemia
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Ovary
- Ovarian Neoplasm
Interacting Proteins
- BRCA1
- CTNNB1
- PRKCD
Pathways
- Cell Proliferation
- Cell Cycle
- Drug Resistance
- Pathogenesis
- Dna Replication
- Dna Repair
- Localization
- Translation
- Cell Division
- Chromosome Condensation
- Reverse Transcription
- Mitosis
- Metaphase
PTMs
- Phosphorylation
- Methylation
- Acetylation
Research Areas
- Cancer
- Cell Cycle and Replication
- Core ESC-Like Genes
- DNA Repair
- Phospho-Specific
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TOP2A
bosterbio.com/bosterbio-gene-info-cards/TOP2A
References
PMID: 2845399 by Tsai-Pflugfelder M., et al. Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22.
PMID: 8393377 by Wasserman R.A., et al. Use of yeast in the study of anticancer drugs targeting DNA topoisomerases: expression of a functional recombinant human DNA topoisomerase II alpha in yeast.