Activated CDC42 kinase 1 Antibodies

AND TNK2 ELISA kits, Activated CDC42 kinase 1 Proteins

Many biological assays use antibodies to detect Activated CDC42 kinase 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Activated CDC42 kinase 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Activated CDC42 kinase 1 antibodies...

We validate the specificity of these antibodies to Activated CDC42 kinase 1 by testing them on tissues known to express TNK2 positively and negatively. Browse below to find the TNK2 antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TNK2 Infographic by Boster Bio

All TNK2 Products

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Specificity

Applications

Price

ACK1 Colorimetric Cell-Based ELISA Kit

Human, Mouse

ELISA

$480
Cat # EKC1014
1 kit, containing one 96-well plate and all necessary reagents

ACK1 (Phospho-Tyr284) Colorimetric Cell-Based ELISA Kit

Human, Mouse

ELISA

$540
Cat # EKC2138
1 kit, containing two 96-well plates and all necessary reagents

Anti-Phospho-ACK (Y284) TNK2 Antibody

Human, Mouse

ELISA, IF, IHC, WB

$380
Cat # A02334Y284
100ul

Anti-ACK TNK2 Antibody

Human, Mouse

ELISA, WB

$380
Cat # A02334
100ul

ACK1 (TNK2) (NM_005781) Human Over-expression Lysate

Human

$960
Cat # LS010188
100 µg

Anti-ACK1/TNK2 Antibody Picoband®

Human

ELISA, Flow Cytometry, WB

$370
Cat # A02334-1
100 μg/vial

TNK2 Overview

Facts about Activated CDC42 kinase 1.

TNK2 3D structure. Source: alphafold

Activated CDC42 kinase 1 (TNK2)

Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin.

Binds to both poly- and mono-ubiquitin and modulates ligand-induced degradation of EGFR, thereby leading to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 that mediates CDC42-dependent cell migration via phosphorylation of BCAR1.

Gene Information

Human
Gene Name:	TNK2
Uniprot:	Q07912
Entrez:	10188

Family

Belongs to:

protein kinase superfamily

Alternative Names

ACK-1; ACK1ACKp21cdc42Hs; activated CDC42 kinase 1; activated Cdc42-associated kinase 1; activated p21cdc42Hs kinase; EC 2.7.10; EC 2.7.10.2; FLJ44758; FLJ45547; Tyrosine kinase non-receptor protein 2; tyrosine kinase, non-receptor, 2

Molecular Weight

Mass (kDA):
114.569 kDA

Genomic Context


Human

Location:	3q29
Sequence:	3; NC_000003.12 (195863364..195909009, complement)

Tissue Specificity

The Tyr-284 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages. It also shows a significant increase in expression in prostate cancers during the progressive stages.

Subcellular Localizations

Cell membrane. Nucleus. Endosome. Cell junction, adherens junction. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle. Membrane, clathrin-coated pit. Cytoplasm, perinuclear region. The Tyr-284 phosphorylated form is found both in the membrane and nucleus. Colocalizes with EGFR on endosomes. Nuclear translocation is CDC42-dependent.