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TNIP1 Antibodies
AND TNIP1 ELISA kits, TNIP1 Proteins
Many biological assays use antibodies to detect TNIP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TNIP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TNIP1 antibodies...
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TNIP1 Overview
Facts about TNFAIP3-interacting protein 1.
TNFAIP3-interacting protein 1 (TNIP1)
Inhibits NF-kappa-B activation and TNF-induced NF-kappa- B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription.
Increases cell surface CD4(T4) antigen expression. Involved in the anti- inflammatory response of macrophages and positively regulates TLR- induced activation of CEBPB.
Gene Information
| Human | |
|---|---|
| Gene Name: | TNIP1 |
| Uniprot: | Q15025 |
| Entrez: | 10318 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ABIN-1; HIV-1 Nef-interacting protein; hVAN; KIAA0113nip40-1; Naf1; NAF1TNFAIP3-interacting protein 1; Nef-associated factor 1 SNP; Nef-associated factor 1; Nip40-1; TNFAIP3 interacting protein 1; VANvirion-associated nuclear-shuttling protein; Virion-associated nuclear shuttling protein
Molecular Weight
Mass (kDA):
71.864 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q33.1 |
| Sequence: | 5; NC_000005.10 (151029943..151087685, complement) |
Tissue Specificity
Ubiquitous. Strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain. In peripheral blood mononucleocytes, isoform 4 is mainly expressed and isoform 1 and isoform 7 are almost not expressed. Expression of isoform 1 and isoform 7 increases in leukemic cells.
Subcellular Localizations
Cytoplasm. Nucleus. Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner.
Diseases
- Arthritis
- Psoriasis
- Rheumatoid Arthritis
- Lupus Erythematosus, Systemic
- Inflammation
- Neoplasms
- Arthritis, Psoriatic
- Autoimmune Diseases
- Autoimmune Reaction
- Autoimmunity
- Rheumatism
- Malignant Neoplasms
- Diffuse Scleroderma
Pathways
- Pathogenesis
- Immune Response
- Inflammatory Response
- Reverse Transcription
- Cell Cycle
- Telomere Maintenance
- Innate Immune Response
- Localization
- Ribosome Biogenesis
- Cell Death
- Cell Growth
- Rna Interference
- Autophagy
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TNIP1
bosterbio.com/bosterbio-gene-info-cards/TNIP1
References
PMID: 9923610 by Fukushi M., et al. Identification and cloning of a novel cellular protein Naf1, Nef- associated factor 1, that increases cell surface CD4 expression.
PMID: 11090181 by Gupta K., et al. A human nuclear shuttling protein that interacts with human immunodeficiency virus type 1 matrix is packaged into virions.