TNFRSF6B Antibodies

Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B)

Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.

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Gene Information

Human
Gene Name:	TNFRSF6B
Uniprot:	O95407
Entrez:	8771

Family

Belongs to:
No superfamily

Alternative Names

DcR3; DCR3Decoy receptor for Fas ligand; Decoy receptor 3; M68; M68DJ583P15.1.1; TNFRSF6B; TR6; TR6DcR3; tumor necrosis factor receptor superfamily member 6B; tumor necrosis factor receptor superfamily, member 6b, decoy

Molecular Weight

Mass (kDA):
32.68 kDA

Genomic Context

Human
Location:	20q13.33
Sequence:	20; NC_000020.11 (63696652..63698684)

Tissue Specificity

Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

Subcellular Localizations

Secreted.

Diseases

• Malignant Neoplasms
• Neoplasms
• Carcinoma
• Malignant Paraganglionic Neoplasm
• Neoplasm Metastasis
• Adenocarcinoma
• Inflammation
• Autoimmune Reaction
• Rheumatoid Arthritis
• Arthritis
• Tissue Adhesions
• Autoimmune Diseases

• Crohn Disease
• Pancreatic Neoplasm
• Inflammatory Bowel Diseases
• Intestinal Diseases
• Esophageal Neoplasms
• Pancreatic Adenocarcinoma
• Malignant Neoplasm Of Stomach

Interacting Proteins

• KRTAP10-9
• TNFSF14

Pathways

• Pathogenesis
• Cell Proliferation
• Cell Death
• Cell Activation
• Secretion
• T Cell Activation
• Immune Response
• Cell Adhesion
• T Cell Proliferation
• Cell Cycle
• Response To Lipopolysaccharide
• Programmed Cell Death
• Inflammatory Response

• Reverse Transcription
• Sensitization
• Chemotaxis
• Cell Differentiation
• Induction Of Apoptosis
• Localization
• Cell Growth

PTMs

• Cleavage

• Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TNFRSF6B

Best Uses of the TNFRSF6B Marker

The TNFRSF6B marker is a great tool for finding a new antibody. It is part of the LIGHT superfamily. This marker is very specific and can be used for all species, including humans. Researchers and scientists from around the world are able to submit their results for species and application to receive product credit. These are the most effective uses of TNFRSF6B Marker.

TNFRSF6B Marker

TNFRSF6B, a novel gene, has many applications in immunotherapy and research into cancer. Boster Bio provides highly specific antibodies that have been validated for use in ELISA, Western Blotting, and Immunohistochemistry. The antibodies are available in a range of concentrations, and have high sensitivity. Scientists who have used Boster Bio products should submit their results for clinical trials.

LIGHT

Researchers are beginning to study a novel immune pathway that involves TNFRSF6B. This protein regulates a number of cellular processes, including the degradation of extracellular matrix and the promotion of tumor metastasis. The protein interacts with plasma membrane and plays a part in signal transduction. Because the protein lacks a transmembrane domain, it may block certain immune monitoring and apoptosis processes. Scientists could use the TNFRSF6B marker to help them understand the role of this protein in autoimmune diseases.

TNFRSF6B can be thought to be involved with the immune system. It may also help explain some pathological processes related to the T-cell response. It also inhibits pseudopodia formation by T cells and interferes wit the interaction of T cell with antigen-presenting tissues. LIGHT can help researchers understand the mechanism of TNFRSF6B by providing costimulatory signals to T cells that stimulate the secretion of Th2 cytokines. The receptor can also activate NF-kappa B which is a co-stimulatory protein that T lymphocytes need to function properly.

TNFRSF6B, in addition to these functions has been implicated with tumor-related signals transduction and cell cycling. The protein is involved in apoptosis, T cell proliferation, and immune regulation. TNFRSF6B also has light-sensitive functions and can bind to sunlight. Similarly, it can stimulate T cell proliferation. Light uses of the TNFRSF6B mark include detection of cancer cells.

A new study identifies a novel tissue marker that may help in predicting the progression of kidney disease. A novel biomarker could be created by combining several risk factors. High TNFRSF6B levels can be used in combination with other risk factors. The predictability of chronic kidney disease may be improved by light-sensing technology. This study is currently ongoing. The final goal of the study is to understand how TNFRSF6B operates.

SUPERFAMILY MEMBERS LIGHT

TNFRSF6B is a member of the TNF superfamily and its encoded protein has a postulated regulatory role in cell death. It competes with other death receptors to ligand binding and acts as a decoy. This gene is located on chromosome twenty and has two transcript variants. One differs in its 5 UTR.

Inflammation plays a major role in the development cancer and autoimmune disorders. The TL1A/death receptor 3 (DR3) axis is a novel immune pathway that regulates immune cell activity. This pathway is a promising target for molecular therapeutics in the treatment of autoimmune diseases and inflammatory disorders. The TNFRSF6B protein is a member of this superfamily and can inhibit several inflammatory processes.

Roadmap Epigenomics MicroRNA targets and Pathway Commons Protein Protein Interactions databases provide annotations for tissue samples that are co-occurring with TNFRSF6B. The Roadmap Epigenomics Cell DNA Methylation Profiles and Tissue DNA Methylation Profiles also identify cell types that have high or low TNFRSF6B gene transcription compared to other types.

Through a search that looked for homology with TNFR genes superfamily, the TNFRSF6B genetic was found in the express sequence tag database. The open reading frame of TNFRSF6B encodes 390 amino acids. It also contains a signal sequence that includes 29 residues and is surrounded by 4 cystein-rich repetitions. TNFRSF6B also has two transcript variants. One differs in its 5’ UTR. It is a non-transmembrane soluble protein.

Other proteins that can be quantified using ELISA

ELISA is a method for the quantitative measurement of protein samples. It can also be used in the detection of multimeric protein. This method was originally used to monitor recombinant C4H Tetramer in crude E.coli extracts. It is a powerful tool to quantify protein and is widely used in food samples and other proteomic applications. Read on to learn more about ELISA.

ELISA, an enzyme-linked immunesorbent assay, measures the concentrations target proteins. These tests can be used to measure the concentration of various antibodies and can also be used for determining serum antibody levels. It can be used for determining the level of antibodies against viruses, such as HIV and West Nile, as well as food allergens. ELISA is also used as a serological blood test for coeliac disease.

A standard curve or well with known protein concentrations is used to calculate the concentration of proteins in an ELISA test. Once a standard curve has been established, a portion is plotted using a linear equation. This value can then be used to calculate the protein concentration. This method has great potential to quantify fibrotic disorders. This method has many benefits over other methods.

ELISA is a commonly used method to measure the protein concentration in biological samples. However, it is not able to measure the concentrations of many proteins in complex mixtures. Non-protein components or protein modifications may affect the concentrations. Some ELISA assays are not compatible with surface-attached peptides, encapsulated protein, and other proteins. To determine the concentration of protein, it is best to consult a laboratory expert.

Boster's high affinity primary antibody

The high-affinity primary antibody for the TMZ domain of TNFRSF6B from Boster Bio has been tested in several formats, including ELISA, IHC, and WB. It reacts with Human, Mouse, and Rat. The antibody is highly specific and highly stable. It reacts with other proteins such as the TNFRSF6B protein.