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- Table of Contents
Facts about Tumor necrosis factor receptor superfamily member 25.
Receptor for TNFSF12/APO3L/TWEAK.
Interacts directly with the adapter TRADD.Mediates activation of NF-kappa-B and causes apoptosis. May play a role in regulating lymphocyte homeostasis.
Human | |
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Gene Name: | TNFRSF25 |
Uniprot: | Q93038 |
Entrez: | 8718 |
Belongs to: |
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No superfamily |
APO3; Apo-3; Apoptosis-inducing receptor AIR; Apoptosis-mediating receptor DR3; Apoptosis-mediating receptor TRAMP; Death receptor 3; DR3; DR3member 12 (translocatingchain-association membrane protein); LARD; Lymphocyte-associated receptor of death; Protein WSL; Protein WSL-1; TNFRSF25; TRAMP; tumor necrosis factor receptor superfamily, member 25; WSL; WSL1; WSL-1
Mass (kDA):
45.385 kDA
Human | |
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Location: | 1p36.31 |
Sequence: | 1; NC_000001.11 (6460786..6466195, complement) |
Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 9]: Cell membrane; Single-pass type I membrane protein.; [Isoform 11]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.; [Isoform 5]: Secreted.; [Isoform 6]: Secreted.; [Isoform 7]: Secreted.; [Isoform 8]: Secreted.; [Isoform 10]: Secreted.; [Isoform 12]: Secreted.
PMID: 8934525 by Kitson J., et al. A death-domain-containing receptor that mediates apoptosis.
PMID: 8875942 by Chinnaiyan A.M., et al. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95.