TLK2 Antibodies

AND TLK2 ELISA kits, TLK2 Proteins

Many biological assays use antibodies to detect TLK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TLK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TLK2 antibodies...

We validate the specificity of these antibodies to TLK2 by testing them on tissues known to express TLK2 positively and negatively. Browse below to find the TLK2 antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TLK2 Infographic by Boster Bio

All TLK2 Products

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Specificity

Applications

Price

Anti-TLK2 Antibody

4 Q&As

Human, Mouse

$399
Cat # A06645
100μl

TLK2 (NM_006852) Human Recombinant Protein

$813
Cat # PROTQ86UE8
20 µg

Anti-TLK2 Mouse Monoclonal Antibody [Clone ID: OTI2G1]

Human, Mouse, Rat

IHC, WB

$523
Cat # M06645-1
100 µl

Anti-TLK2 Mouse Monoclonal Antibody [Clone ID: OTI2H2]

Human, Mouse, Rat

Flow Cytometry, IHC

$523
Cat # M06645-2
100 µl

Anti-TLK2 Mouse Monoclonal Antibody [Clone ID: OTI2D10]

Human, Mouse, Rat

IHC

$523
Cat # M06645
100 µl

TLK2 (NM_006852) Human Over-expression Lysate

Human

$960
Cat # LS011011
100 µg

TLK2 Overview

Facts about Serine/threonine-protein kinase tousled-like 2.

TLK2 3D structure. Source: alphafold

Serine/threonine-protein kinase tousled-like 2 (TLK2)

Serine/threonine-protein kinase involved in the process of chromatin assembly and likely also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B.

Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.

Gene Information

Human
Gene Name:	TLK2
Uniprot:	Q86UE8
Entrez:	11011

Family

Belongs to:

protein kinase superfamily

Alternative Names

EC 2.7.11; EC 2.7.11.1; MGC44450; PKU-ALPHA; serine/threonine-protein kinase tousled-like 2; tousled-like kinase 2serine/threonine kinase

Molecular Weight

Mass (kDA):
87.661 kDA

Genomic Context


Human

Location:	17q23.2
Sequence:	17; NC_000017.11 (62470908..62615481)

Tissue Specificity

Ubiquitous. Detected in placenta, fetal liver, kidney, pancreas, heart and skeletal muscle. Highly expressed in testis. Detected in spleen, thymus, colon, ovary, small intestine, prostate and peripheral blood leukocytes.

Subcellular Localizations

Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region at S phase and in the nucleus at late G2.

Diseases

Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Breast
Mammary Neoplasms
Autoimmunity
Fracture Of First Cervical Vertebra
Aneuploidy
Infertility
Lupus Erythematosus, Systemic
Chromosome Breakage
Cytogenetic Abnormality
Infective Disorder

Malignant Neoplasm Of Prostate
Neuroblastoma
Glioblastoma Multiforme
Cell Transformation, Neoplastic
Central Nervous System Neoplasms
Congenital Abnormality
Male Infertility

Interacting Proteins

IRF4
IRF7

Pathways

Chromosome Segregation
Localization
Dna Replication
Chromatin Assembly
Cytokinesis
Mitosis
Dna Repair
S Phase
Stem Cell Differentiation
Flower Development
Fertilization
Histone Modification
Double-strand Break Repair

Spermatogenesis
Cell Cycle
Sister Chromatid Cohesion
Cell Differentiation
Chromosome Condensation
Leaf Development
Spindle Assembly

PTMs

Phosphorylation

Cleavage

Dephosphorylation

Research Areas

Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TLK2

References

PMID: 9427565 by Yamakawa A., et al. cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal.

PMID: 10523312 by Sillje H.H.W., et al. Mammalian homologues of the plant tousled gene code for cell-cycle- regulated kinases with maximal activities linked to ongoing DNA replication.