TJP3 Antibodies

AND TJP3 ELISA kits, TJP3 Proteins

Many biological assays use antibodies to detect TJP3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TJP3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TJP3 antibodies...

We validate the specificity of these antibodies to TJP3 by testing them on tissues known to express TJP3 positively and negatively. Browse below to find the TJP3 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TJP3 Infographic by Boster Bio

All TJP3 Products

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Product

Figures

Specificity

Applications

Price

Anti-Zonula occludens protein 3/TJP3 Antibody Picoband®

Human

IF, ICC, WB

$370
Cat # PA1972
100 μg/vial

Anti-Zonula occludens protein 3/TJP3 Antibody Picoband®

7 Q&As

Mouse, Rat

IHC, WB

$370
Cat # PA1973
100 μg/vial

Zonula occludens protein 3 (TJP3) (NM_014428) Human Recombinant Protein

$1062
Cat # PROTO95049
20 µg

Zonula occludens protein 3 (TJP3) (NM_014428) Human Over-expression Lysate

Human

$960
Cat # LS027134
100 µg

TJP3 Overview

Facts about Tight junction protein ZO-3.

TJP3 3D structure. Source: alphafold

Tight junction protein ZO-3 (TJP3)

TJP1, TJP2, and TJP3 are closely related scaffolding proteins which connect tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space as well as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells.

Binds and recruits PATJ to tight junctions in which it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle development through the sequestration of cyclin D1 (CCND1) at tight junctions through mitosis which prevents CCND1 degradation through M-phase and enables S-phase transition (PubMed:21411630).

Gene Information

Human
Gene Name:	TJP3
Uniprot:	O95049
Entrez:	27134

Family

Belongs to:

MAGUK family

Alternative Names

MGC119546; tight junction protein 3 (zona occludens 3); Tight junction protein 3; ZO-3; ZO3tight junction protein ZO-3; zona occludens 3; Zona occludens protein 3; Zonula occludens protein 3

Molecular Weight

Mass (kDA):
101.397 kDA

Genomic Context


Human

Location:	19p13.3
Sequence:	19; NC_000019.10 (3708384..3750813)

Subcellular Localizations

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction. Nucleus. Exhibits predominant nuclear expression in proliferating cells but is exclusively junctionally expressed after confluence is reached (PubMed:23608536). Shows an epithelial-specific tight junction localization in a TJP1/TJP2-dependent fashion (By similarity).