TJP1 Antibodies

AND TJP1 ELISA kits, TJP1 Proteins

Many biological assays use antibodies to detect TJP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TJP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TJP1 antibodies...

We validate the specificity of these antibodies to TJP1 by testing them on tissues known to express TJP1 positively and negatively. Browse below to find the TJP1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TJP1 Infographic by Boster Bio

All TJP1 Products

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Product

Figures

Specificity

Applications

Price

Anti-ZO1 tight junction protein/TJP1 Antibody Picoband®

32 Citations 5 Q&As

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # PB9234
100 μg/vial

Anti-TJP1 Antibody Picoband® (monoclonal, 3E12)

3 Citations

Human

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M00860
100 μg/vial

Anti-ZO1 Rabbit monoclonal TJP1 Antibody

2 Citations

Human, Mouse, Rat

IHC, ICC

$482
Cat # M00860-1
100ul

TJP1 (NM_003257) Human Over-expression Lysate

Human

$960
Cat # LS007082
100 µg

TJP1 Overview

Facts about Tight junction protein ZO-1.

TJP1 3D structure. Source: alphafold

Tight junction protein ZO-1 (TJP1)

TJP1, TJP2, and TJP3 are closely related scaffolding proteins which link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). The tight junction functions to restrict movement of substances through the paracellular space as well as a border between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial tissues.

Necessary for lumenogenesis, and especially efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB into the leading edge of migrating cells (PubMed:21240187).

Gene Information

Human
Gene Name:	TJP1
Uniprot:	Q07157
Entrez:	7082

Family

Belongs to:

MAGUK family

Alternative Names

DKFZp686M05161; MGC133289; tight junction protein 1 (zona occludens 1); Tight junction protein 1; tight junction protein ZO-1; TJP1; ZO1; ZO-1; zona occludens 1; Zona occludens protein 1; zonula occludens 1 protein; Zonula occludens protein 1

Molecular Weight

Mass (kDA):
195.459 kDA

Genomic Context


Human

Location:	15q13.1
Sequence:	15; NC_000015.10 (29699367..29969049, complement)

Tissue Specificity

The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules.

Subcellular Localizations

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction. Cell junction. Cell junction, gap junction. Cell projection, podosome. Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact (PubMed:7798316). At podosomal sites, is predominantly localized in the ring structure surrounding the actin core (PubMed:20930113).

Diseases

Tissue Adhesions
Inflammation
Neoplasms
Malignant Neoplasms
Carcinoma
Nervousness
Edema
Cell Invasion
Neoplasm Metastasis
Corneal Diseases
Intestinal Diseases
Colitis
Inflammatory Bowel Diseases

Adenocarcinoma
Hypoxia
Kidney Diseases
Retinal Diseases
Diabetes Mellitus
Extravasation
Sclerosis

Interacting Proteins

ACTN4
GJA1
GJD3
KIRREL1
Wwtr1

Pathways

Localization
Transport
Pathogenesis
Cell Adhesion
Secretion
Cell-cell Adhesion
Cell Proliferation
Cell Differentiation
Spermatogenesis
Cell Migration
Cell Death
Wound Healing
Endocytosis

Cell Cycle
Tight Junction Assembly
Cell Growth
Regeneration
Angiogenesis
Glomerular Filtration
Translation

PTMs

Phosphorylation
Dephosphorylation
Cleavage
Reduction
Methylation
Biotinylation
Nitration
Glycosylation
Demethylation
Deamidation

Ubiquitination
Sumoylation
Carboxylation
Phosphorothioation
Amidation
Gamma-cleavage
Prenylation
Ribosylation
Acetylation
Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TJP1

References

PMID: 8395056 by Willott E., et al. The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.

PMID: 7798316 by Furuse M., et al. Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.

34 Publications of Boster TJP1 Antibodies & ELISA Kits

PubMed ID: PMID:26191218, Protective effect of salvianolic acid B on NASH rat liver through restoring inte...
PubMed ID: 10.7150/thno.13532, Dual Receptor Recognizing Cell Penetrating Peptide for Selective Targeting, Effi...
PubMed ID: 10.4314/tjpr.v17i3.5, Effect of pinocembrin pre-treatment on expressions of Cx43 protein and claudin 1...
PubMed ID: 10.3892/etm.2021.10607, Piperazine ferulate prevents high‑glucose‑induced filtration barrier injury ...
PubMed ID: 10.3390/molecules26144149, The Regulatory Effects of Licochalcone A on the Intestinal Epithelium and Gut Mi...
PubMed ID: 10.3389/fmicb.2020.622354, Prevention and Alleviation of Dextran Sulfate Sodium Salt-Induced Inflammatory B...
PubMed ID: 10.1159/000358235, The Neurovascular Protective Effects of Huperzine A on D-Galactose-Induced Infla...
PubMed ID: 10.1111/1440-1681.12321, Transplantation of human umbilical mesenchymal stem cells attenuates dextran sul...
PubMed ID: 10.1093/femspd/ftx104, Vancomycin and ceftriaxone can damage intestinal microbiota and affect the devel...
PubMed ID: 10.1016/j.jff.2021.104661, Genetically encoded probiotic EcN 1917 alleviates alcohol-induced acute liver in...
PubMed ID: 10.1016/j.jff.2020.104045, Bifidobacterium breve ATCC15700 pretreatment prevents alcoholic liver disease th...
PubMed ID: 10.1016/j.freeradbiomed.2019.09.015, Protective effects of acarbose against vascular endothelial dysfunction through ...
PubMed ID: 10.1016/j.fct.2018.01.004, Essential roles of Akt/Snail pathway in microcystin-LR-induced tight junction to...
PubMed ID: 10.1016/j.ejphar.2021.174730, Licoflavone B, an isoprene flavonoid derived from licorice residue, relieves dex...
PubMed ID: 10.1016/j.brainres.2015.08.003, Intranasal administration of human umbilical cord mesenchymal stem cells-conditi...
PubMed ID: 10.1007/s40520-013-0148-0, Age-related changes in small intestinal mucosa epithelium architecture and epith...
PubMed ID: 10.1002/mnfr.201500181, Procyanidin B2 attenuates neurological deficits and blood–brain barrier disrup...
PubMed ID: 10.1002/bit.27589, Hydrogel microfluidic‐based liver‐on‐a‐chip: Mimicking the mass transfer...
PubMed ID: 10.1002/bit.27589, Hydrogel microfluidic‐based liver‐on‐a‐chip: Mimicking the mass transfer...
PubMed ID: 10.1002/bit.27589, Hydrogel microfluidic‐based liver‐on‐a‐chip: Mimicking the mass transfer...
PubMed ID: , Comparing ex vivo and in vitro translocation of silver nanoparticles and ions ...

*Showing only the more recent 20. More publications can be found for each product on its corresponding product page