TGFBI Antibodies

Transforming growth factor-beta-induced protein ig-h3 (TGFBI)

Plays a role in cell adhesion (PubMed:8024701). May play a role in cell-collagen interactions (By similarity).

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Gene Information

Human
Gene Name:	TGFBI
Uniprot:	Q15582
Entrez:	7045

Family

Belongs to:
No superfamily

Alternative Names

beta IGH3; beta IG-H3; BIGH3EBMD; CDB1; CDG2; CDGG1transforming growth factor, beta-induced, 68kD; CSD; CSD1; CSD2; CSD3; Kerato-epithelin; LCD1; RGD-CAP; RGD-containing collagen-associated protein; TGFBI; TGFBIP; transforming growth factor, beta-induced, 68kDa; transforming growth factor-beta-induced protein ig-h3

Molecular Weight

Mass (kDA):
74.681 kDA

Genomic Context

Human
Location:	5q31.1
Sequence:	5; NC_000005.10 (136028988..136063818)

Tissue Specificity

Highly expressed in the corneal epithelium (PubMed:27609313, PubMed:8077289). Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas (PubMed:8077289).

Subcellular Localizations

Secreted. Secreted, extracellular space, extracellular matrix. May be associated both with microfibrils and with the cell surface (PubMed:8077289).

Diseases

• Dystrophy
• Hereditary Corneal Dystrophy
• Corneal Diseases
• Familial Amyloid Polyneuropathy, Type V
• Granular Corneal Dystrophy
• Avellino Corneal Dystrophy
• Neoplasms
• Malignant Neoplasms
• Amyloidosis
• Plaque, Amyloid
• Corneal Dystrophy, Lattice Type 3

• Tissue Adhesions
• Carcinoma
• Corneal Deposits
• Amyloid Deposition
• Neoplasm Metastasis

Interacting Proteins

• FAM9B

Pathways

• Pathogenesis
• Cell Adhesion
• Cell Proliferation
• Cell Cycle
• Methylation
• Aging
• Localization
• Cell Death
• Cell Differentiation
• Reverse Transcription
• Wound Healing
• Angiogenesis
• Secretion

• Amyloid Fibril Formation
• Dna Methylation
• Inflammatory Response
• Chemotaxis
• Cell Growth
• Clathrin-mediated Endocytosis
• Cell Migration

PTMs

• Methylation
• Phosphorylation

• Demethylation
• Cleavage

• Biotinylation

Research Areas

• Angiogenesis
• Cytokine Research
• Immunology
• Vision

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TGFBI

Best Uses Of The TGFBI Marker

The TGFBI marker can be used for many purposes. These include detecting tumor cells and studying the growth or cancer-cells. Although it is unlikely that TGFBR1 mutation was caused DNA damage, it is highly mutational and could be used to help researchers determine if they increase the risk of malignancy.

TGFBR1 gene

The TGFBR1 protein is encoded by the instructions to make the Transforming Growth Factor Beta Receptor Type 1 (TGFBR1) gene. The TGFBR1 signal carries signals into the cells, which can influence cell growth and division. TGFBR1-related markers measure the level of TGF-1b1, which is demonstrated by its ability to increase expression of ETS1 or BMPR2. The TGFBR1 -related marker can be used for many purposes. Researchers can also use it to better understand TGF-1b1’s role in the immune systems.

Scientists have also used TGFBR1 genes as markers for cancer. TGFBR1 may help determine if cancerous tumors are because it regulates the expressions of other cancer-related gene. Researchers have used TGFBR1 as an indicator of tumor growth to identify aggressive patterns. Scientists have discovered a new type of cancer marker by using TGFBR1 genes markers. It is highly specific, and can help doctors select the right drug to treat a patient's particular cancer.

The TGFBR1 genetic instructions tell cells to make the TGF beta receptor type 1 (TGFBR1), as instructed by the TGFBR1 gene. The TGFBR1 receptor transmits signals from the outside to the cell, through a process known as signal transduction. The signals transmit messages to regulate cell activity, growth and division as well as metabolism. Numerous cancer-related research has linked the TGFBR1 genes to several studies, including one on the aging process as well as diabetes. It is important to continue research in order to understand how this gene affects human health and development.

Many cells can make the TGFBR1 protein. It plays a key role in bone remodeling by causing osteoblasts proliferation, differentiation, and chemotaxis. It activates CREB3L1, which regulates production of plasminogen inhibitor-1 (PAI-1) in a receptor negative cell line. This gene can also be used to treat osteoarthritis and bone regrowth.

The anti-TGF-1b1 antibody is made from mouse ascites. It is highly stable at temperatures between -20 and 4 degrees Celsius and has an affinity for Human. The antibody is available as a vial containing sodium chloride (trehalose) and Na2HPO4.

TGFBR1 has a crucial role in the immune systems, but its functions remain unclear. It regulates many cellular processes, including inflammation, angiogenesis, and is not required for the development or function of hematopoietic precursor cells or functional hemotopoiesis. Its expression does not correlate with patient characteristics. Nonetheless, it is worth considering the gene for its potential applications.

Many scientists are concerned about the safety of these products and the efficacy of TGFBR1 genes. Boster Bio is a trusted company. Its anti TGF-beta1 antibody has a cross-reactive nature and a high sensitivity to human TGFB1. The company is highly affordable and has excellent customer service.

Transmembrane glycoprotein TGF-b is a receptor for this transmembrane glycoprotein. It is induced in different cell types by TGF-b. It also contributes to the elevated ROS production in KO cells. It was also linked to an increase in ROS production through the upregulation Nox4. TGFb-dependent ROS generation in KO cells was also critical for enhanced features of myofibroblasts, while other gene program features such as angiogenic/inflammatory are not affected.

TGFBR1 gene expression

TGFBR1 genes encode instructions for transforming grow factor beta receptor type 1. It transmits signals from the inner parts of cells to enable them to respond to external circumstances. Numerous cancer-related research has linked TGFBR1 gene manifestation. Many mutations have occurred in the TGFBR1 human gene. Researchers must understand how it works in the body.

TGFBR1 can be found in a variety of cell types. Some of these proteins can be expressed by immune cells. TGFBR1 can be expressed by some types of immune cells. TGFBR1 is expressed in various types of tumors. This indicates the presence or absence of cancer cells. This gene is also involved as a producer of cytokine, a hormone.

TGFb induces the expression nox4 in a variety cell types. This gene is essential to TGF-b-mediated myofibroblast activation. TGFb-dependent ROS is a key pathophysiological feature of KO-cells. WT and KKO cells had similar Nox4 gene levels. However, TGF-b inhibition did not affect other genes or angiogenic features of KO cells.

TGFBR1 can be used to study many different types of cancers. The protein can be found in macrophages. fibroblasts. As it has a central role in the regulation of the production of cytokines, it is useful in research involving the role of TGFBR1 in cancer.