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TERT Antibodies
AND TERT ELISA kits, TERT Proteins
Many biological assays use antibodies to detect TERT, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TERT in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TERT antibodies...
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TERT Infographic by Boster Bio
All TERT Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$480
Cat # EKC1561
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1561
1 kit, containing one 96-well plate and all necessary reagents
Human
ELISA
$540
Cat # EKC2328
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2328
1 kit, containing two 96-well plates and all necessary reagents
Human
$960
Cat # LS007015
100 µg
Cat # LS007015
100 µg
TERT Overview
Facts about Telomerase reverse transcriptase.
Telomerase reverse transcriptase (TERT)
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in many eukaryotes. Inactive, or very low activity, in normal somatic cells.
Catalytic component of the teleromerase holoenzyme complex whose primary activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA- dependent extension of 3'-chromosomal termini using the 6- nucleotide telomeric repeat unit, 5'-TTAGGG-3'.
Gene Information
| Human | |
|---|---|
| Gene Name: | TERT |
| Uniprot: | O14746 |
| Entrez: | 7015 |
Family
| Belongs to: |
|---|
| reverse transcriptase family |
Alternative Names
EST2Telomerase-associated protein 2; hEST2; hTERT; TCS1EC 2.7.7.49; Telomerase catalytic subunit; telomerase reverse transcriptase; TERT; TP2HEST2; TRTEC 2.7.7
Molecular Weight
Mass (kDA):
126.997 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5p15.33 |
| Sequence: | 5; NC_000005.10 (1253148..1295068, complement) |
Tissue Specificity
Expressed at a high level in thymocyte subpopulations, at an intermediate level in tonsil T-lymphocytes, and at a low to undetectable level in peripheral blood T- lymphocytes.
Subcellular Localizations
Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Chromosome, telomere. Cytoplasm. Nucleus, PML body. Shuttling between nuclear and cytoplasm depends on cell cycle, phosphorylation states, transformation and DNA damage. Diffuse localization in the nucleoplasm. Enriched in nucleoli of certain cell types. Translocated to the cytoplasm via nuclear pores in a CRM1/RAN-dependent manner involving oxidative stress-mediated phosphorylation at Tyr-707. Dephosphorylation at this site by SHP2 retains TERT in the nucleus. Translocated to the nucleus by phosphorylation by AKT.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Cell Transformation, Neoplastic
- Telomere Shortening
- Carcinogenesis
- Mammary Neoplasms
- Leukemia
- Adenocarcinoma
- Malignant Squamous Cell Neoplasm
- Lung Neoplasms
Interacting Proteins
- CTNNB1
- GNL3
- RUVBL1
- SMARCA4
- UPF1
Pathways
- Senescence
- Cell Proliferation
- Cell Cycle
- Telomere Maintenance
- Cell Growth
- Aging
- Cell Death
- Methylation
- Cellular Senescence
- Localization
- Pathogenesis
- Rna Interference
- Dna Methylation
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Acetylation
- Oxidation
- Demethylation
- Hydroxylation
Research Areas
- Autophagy
- Cancer
- Cellular Markers
- Chromatin Research
- DNA Repair
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TERT
bosterbio.com/bosterbio-gene-info-cards/TERT
References
PMID: 9288757 by Meyerson M., et al. hEST2, the putative human telomerase catalytic subunit gene, is up- regulated in tumor cells and during immortalization.
PMID: 9252327 by Nakamura T.M., et al. Telomerase catalytic subunit homologs from fission yeast and human.
4 Publications of Boster TERT Antibodies & ELISA Kits
- PubMed ID: 10.4161/cbt.8.10.8117, Adenoviral mediated transduction of adenoid cystic carcinoma by human TRAIL gene...
- PubMed ID: 10.3892/or.19.2.575, Long-term effects of short hairpin RNA-targeted human telomerase reverse transcr...
- PubMed ID: 10.1007/s12250-008-2914-2, Expression of human papillomavirus in mammary carcinoma and its possible mechani...
- PubMed ID: 20692298, Yang S, Brindley Pj, Zeng Q, Li Y, Zhou J, Liu Y, Liu B, Cai L, Zeng T, Wei Q, L...
*More publications can be found for each product on its corresponding product page