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Angiopoietin-1 receptor Antibodies
AND TEK ELISA kits, Angiopoietin-1 receptor Proteins
Many biological assays use antibodies to detect Angiopoietin-1 receptor, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Angiopoietin-1 receptor in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Angiopoietin-1 receptor antibodies...
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TEK Infographic by Boster Bio
All TEK Products
Product
Figures
Specificity
Applications
Price
Human TIE2/TEK ELISA Kit PicoKine®
3 Citations 4 Q&As
Human
ELISA
$499
Cat # EK0519
96 wells/kit, with removable strips.
Cat # EK0519
96 wells/kit, with removable strips.
Mouse TIE2/TEK ELISA Kit PicoKine®
1 Citations 9 Q&As
Mouse
ELISA
$499
Cat # EK0976
96 wells/kit, with removable strips.
Cat # EK0976
96 wells/kit, with removable strips.
Anti-TIE2/TEK Antibody Picoband®
4 Citations
Human, Mouse, Rat
IHC, WB
$370
Cat # A01274-1
100 μg/vial
Cat # A01274-1
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01274-2
100 μg/vial
Cat # A01274-2
100 μg/vial
TEK Overview
Facts about Angiopoietin-1 receptor.
Angiopoietin-1 receptor (TEK)
Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and modulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels.
Required for normal angiogenesis and heart development during embryogenesis. Required for post- natal hematopoiesis.
Gene Information
| Human | |
|---|---|
| Gene Name: | TEK |
| Uniprot: | Q02763 |
| Entrez: | 7010 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
angiopoietin-1 receptor; CD202b antigen; CD202b; EC 2.7.10; EC 2.7.10.1; hTIE2; p140 TEK; soluble TIE2 variant 1; soluble TIE2 variant 2; TEK tyrosine kinase, endothelial; TEK; Tie2; Tie-2; TIE2CD202b; Tunica interna endothelial cell kinase; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2; venous malformations, multiple cutaneous and mucosal; VMCM; VMCM1
Molecular Weight
Mass (kDA):
125.83 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9p21.2 |
| Sequence: | 9; NC_000009.12 (27109141..27230178) |
Tissue Specificity
Detected in umbilical vein endothelial cells. Proteolytic processing gives rise to a soluble extracellular domain that is detected in blood plasma (at protein level). Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Secreted. Recruited to cell-cell contacts in quiescent endothelial cells (PubMed:18425120, PubMed:18425119). Colocalizes with the actin cytoskeleton and at actin stress fibers during cell spreading. Recruited to the lower surface of migrating cells, especially the rear end of the cell. Proteolytic processing gives rise to a soluble extracellular domain that is secreted (PubMed:11806244).
Diseases
- Tumor Angiogenesis
- Neoplasms
- Pathologic Neovascularization
- Malignant Neoplasms
- Neoplasm Metastasis
- Carcinoma
- Tissue Adhesions
- Inflammation
- Hypoxia
- Malignant Paraganglionic Neoplasm
- Mammary Neoplasms
- Hemorrhage
Interacting Proteins
- ANGPT2
- PTPN12
- PTPRB
- PTPRC
- PTPRJ
- PTPRK
- PTPRO
Pathways
- Angiogenesis
- Pathogenesis
- Cell Migration
- Vasculogenesis
- Cell Adhesion
- Cell Proliferation
- Localization
- Regeneration
- Transport
- Cell Death
- Cell Growth
- Ossification
- Mating
PTMs
- Phosphorylation
- Acetylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TEK
bosterbio.com/bosterbio-gene-info-cards/TEK
References
PMID: 8382358 by Ziegler S.F., et al. Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta.
PMID: 9204896 by Maisonpierre P.C., et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.
7 Publications of Boster Angiopoietin-1 receptor Antibodies & ELISA Kits
- PubMed ID: 10.3980/j.issn.2222-3959.2014.04.11, Effects of laser photocoagulation on serum angiopoietin-1, angiopoietin-2, angio...
- PubMed ID: 10.1620/tjem.224.221, Exercise Improves Recovery after Ischemic Brain Injury by Inducing the Expressio...
- PubMed ID: 10.1016/j.transproceed.2008.08.047, Rapamycin and Cyclosporine Have Different Effects on Expression of ang-1 and ang...
- PubMed ID: 10.1016/j.transproceed.2008.07.121, Expressions of Angiopoietin-1, Angiopoietin-2, and Tie2 and Their Roles in Rat R...
- PubMed ID: 10.1016/j.neuroscience.2017.11.027, Transplantation of Human Umbilical Cord Blood Mononuclear Cells Attenuated Ische...
- PubMed ID: 25161936, Effects of laser photocoagulation on serum angiopoietin-1, angiopoietin-2, angio...
- PubMed ID: 25831422, Sancakdar E, Guven As, Uysal Eb, Deveci K, G??lt??rk E. Pediatr Infect Dis J. 20...
*More publications can be found for each product on its corresponding product page