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- Table of Contents
Facts about Alpha-tectorin.
Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. .
Human | |
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Gene Name: | TECTA |
Uniprot: | O75443 |
Entrez: | 7007 |
Belongs to: |
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No superfamily |
alpha-tectorin; DFNA12; DFNA8; DFNB21; tectorin alpha
Mass (kDA):
239.527 kDA
Human | |
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Location: | 11q23.3 |
Sequence: | 11; NC_000011.10 (121101243..121191490) |
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix. Found in the non-collagenous matrix of the tectorial membrane.
PMID: 9590290 by Verhoeven K., et al. Mutations in the human alpha-tectorin gene cause autosomal dominant non-syndromic hearing impairment.
PMID: 21368133 by Zheng J., et al. Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4).