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- Table of Contents
Facts about Tectonin beta-propeller repeat-containing protein 1.
Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. .
Human | |
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Gene Name: | TECPR1 |
Uniprot: | Q7Z6L1 |
Entrez: | 25851 |
Belongs to: |
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TECPR1 family |
DKFZP434B0335; FLJ23419; FLJ90593; KIAA1358; tectonin beta-propeller repeat containing 1; tectonin beta-propeller repeat-containing protein 1
Mass (kDA):
129.696 kDA
Human | |
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Location: | 7q21.3 |
Sequence: | 7; NC_000007.14 (98214624..98252235, complement) |
Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Localizes to Lysosome membranes, and binds PtdIns(3)P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes.
PMID: 21575909 by Ogawa M., et al. A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens.
PMID: 22342342 by Chen D., et al. A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate.