TCIRG1 Antibodies

AND TCIRG1 ELISA kits, TCIRG1 Proteins

Many biological assays use antibodies to detect TCIRG1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TCIRG1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TCIRG1 antibodies...

We validate the specificity of these antibodies to TCIRG1 by testing them on tissues known to express TCIRG1 positively and negatively. Browse below to find the TCIRG1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TCIRG1 Infographic by Boster Bio

All TCIRG1 Products

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Product

Figures

Specificity

Applications

Price

Anti-TCIRG1 Antibody

Human, Mouse, Rat

ELISA, WB

$449
Cat # A05045
0.1 mg

TCIRG1 (NM_006019) Human Over-expression Lysate

Human

$628
Cat # LS010312
100 µg

TCIRG1 Overview

Facts about V-type proton ATPase 116 kDa subunit a isoform 3.

TCIRG1 3D structure. Source: alphafold

V-type proton ATPase 116 kDa subunit a isoform 3 (TCIRG1)

Part of the proton channel of V-ATPases (By similarity). Appears to be directly involved in T-cell activation.

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Gene Information

Human
Gene Name:	TCIRG1
Uniprot:	Q13488
Entrez:	10312

Family

Belongs to:

V-ATPase 116 kDa subunit family

Alternative Names

a3; Atp6i; ATP6N1C; ATP6N1Cspecific 116-kDa vacuolar proton pump subunit; ATP6V0A3T-cell immune response cDNA 7; OC-116 kDa; OC116; OC-116; OC-116kDa; OC116Vph1; OPTB1; Osteoclastic proton pump 116 kDa subunit; Stv1; T-cell immune regulator 1; T-cell immune response cDNA7 protein; T-cell, immune regulator 1; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein aisoform 3; T-cell, immune regulator 1, ATPase, H+ transporti

Molecular Weight

Mass (kDA):
92.968 kDA

Genomic Context


Human

Location:	11q13.2
Sequence:	11; NC_000011.10 (68039000..68053846)

Tissue Specificity

Isoform long is highly expressed in osteoclastomas. Isoform short is highly expressed in thymus.

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Diseases

Albers-schonberg Disease
Malignant Paraganglionic Neoplasm
Infantile Malignant Osteopetrosis
Bone Diseases
Fracture
Pancytopenia
Osteosclerosis
Blind Vision
Hereditary Diseases
Visual Impairment
Optic Atrophy
Atrophy

Arthritis
Hypertensive Disease
Genetic Diseases, Inborn
Nerve Compression
Sclerosis
Macrocephaly

Pathways

Bone Resorption
Secretion
Osteoclast Differentiation
Immune Response
Pathogenesis
Transport
Cell Activation
T Cell Activation
T Cell Proliferation
Cell Proliferation
Bone Remodeling
Acid Secretion
Localization

Cytokine Production
Lymphocyte Activation
Osteoclast Development
Proton Transport
Osteoblast Differentiation
Proteolysis
Virulence

PTMs

Phosphorylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TCIRG1

References

PMID: 8579597 by Li Y.P., et al. Molecular cloning and characterization of a putative novel human osteoclast-specific 116-kDa vacuolar proton pump subunit.

PMID: 10329006 by Heinemann T., et al. Genomic organization of the gene coding for TIRC7, a novel membrane protein essential for T cell activation.