TAP2 Antibodies

AND TAP2 ELISA kits, TAP2 Proteins

Many biological assays use antibodies to detect TAP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TAP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TAP2 antibodies...

We validate the specificity of these antibodies to TAP2 by testing them on tissues known to express TAP2 positively and negatively. Browse below to find the TAP2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TAP2 Infographic by Boster Bio

All TAP2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-TAP2 Antibody Picoband®

1 Q&As

Human

$370
Cat # PB9824
100 μg/vial

Anti-Antigen peptide transporter 2 TAP2 Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$405
Cat # A01496
100ul

TAP2 (NM_018833) Human Over-expression Lysate

Human

$960
Cat # LS006891
100 µg

TAP2 Overview

Facts about Antigen peptide transporter 2.

TAP2 3D structure. Source: alphafold

Antigen peptide transporter 2 (TAP2)

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the last stage of MHC class I folding, namely the binding of peptide.

Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP.

Gene Information

Human
Gene Name:	TAP2
Uniprot:	Q03519
Entrez:	6891

Family

Belongs to:

ABC transporter superfamily

Alternative Names

ABC18; ABCB3; ABCB3ABC18; antigen peptide transporter 2; APT2; ATP-binding cassette, sub-family B (MDR/TAP), member 3; D6S217E; MHC 2; Peptide transporter involved in antigen processing 2; Peptide transporter PSF2; Peptide transporter TAP2; PSF2; PSF2PSF-2; Really interesting new gene 11 protein; RING11; RING11ATP-binding cassette sub-family B member 3; TAP2; transporter 2, ABC (ATP binding cassette); transporter 2, ATP-binding cassette, sub-family B (MDR/TAP); Y1

Molecular Weight

Mass (kDA):
75.664 kDA

Genomic Context


Human

Location:	6p21.32
Sequence:	6; NC_000006.12 (32821833..32838770, complement)

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein. The transmembrane segments seem to form a pore in the membrane.

Diseases

Neoplasms
Malignant Neoplasms
Dysequilibrium Syndrome
Carcinoma
Melanoma
Autoimmune Reaction
Malignant Paraganglionic Neoplasm
Diabetes Mellitus
Virus Diseases
Autoimmune Diseases
Diabetes Mellitus, Insulin-dependent
Arthritis

Vaccinia
Rheumatoid Arthritis
Influenza
Tumor Escape
Infective Disorder
Neoplasm Metastasis
Hepatitis

Interacting Proteins

TAP1
TAPBP

Pathways

Transport
Peptide Transport
Immune Response
Pathogenesis
Antigen Processing And Presentation
Cell Recognition
Localization
Proteolysis
Translation
Glycosylation
Dna Replication
Cell Cycle
Secretion

Intracellular Transport
Methylation
Secretory Pathway
Cell Proliferation
Adaptive Immune Response
Inflammatory Response
Reverse Transcription

PTMs

Cleavage
Glycosylation
Phosphorylation
Methylation

Formylation
Ubiquitination
Acetylation
Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TAP2

References

PMID: 1453454 by Beck S., et al. DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing.

PMID: 1741401 by Powis S.H., et al. Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex.