Transcription initiation factor TFIID subunit 1 (TAF1)

Largest part and core scaffold of the TFIID basal transcription factor complex (PubMed:25412659, PubMed:27007846). Contains publication N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors.

Phosphorylates TP53 on'Thr-55' which leads to MDM2- mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues.