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TACC3 Antibodies
AND TACC3 ELISA kits, TACC3 Proteins
Many biological assays use antibodies to detect TACC3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TACC3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TACC3 antibodies...
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TACC3 Infographic by Boster Bio
All TACC3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M02876
100 μl
Cat # M02876
100 μl
Human
Flow Cytometry, IF, IHC, WB
$523
Cat # M02876-1
100 µl
Cat # M02876-1
100 µl
Human, Rat
Flow Cytometry, IF, WB
$523
Cat # M02876-2
100 µl
Cat # M02876-2
100 µl
TACC3 Overview
Facts about Transforming acidic coiled-coil-containing protein 3.
Transforming acidic coiled-coil-containing protein 3 (TACC3)
Plays a role in the microtubule-dependent coupling of the nucleus along with the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity).
Acts as component of this TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is necessary for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825).
Gene Information
| Human | |
|---|---|
| Gene Name: | TACC3 |
| Uniprot: | Q9Y6A5 |
| Entrez: | 10460 |
Family
| Belongs to: |
|---|
| TACC family |
Alternative Names
ERIC-1; ERIC1ERIC-1; MGC117382; MGC133242; TACC3; transforming acidic coiled-coil-containing protein 3; transforming, acidic coiled-coil containing protein 3
Molecular Weight
Mass (kDA):
90.36 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4p16.3 |
| Sequence: | 4; NC_000004.12 (1721497..1745171) |
Subcellular Localizations
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. In complex with CKAP5 localized to microtubule plus-ends in mitosis and interphase. In complex with CKAP5 and clathrin localized to inter-microtubule bridges in mitotic spindles.
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Transformation, Neoplastic
- Carcinoma
- Hypoxia
- Malignant Neoplasm Of Breast
- Aneuploidy
- Lymphoma
- Ovarian Neoplasm
- Tumor Progression
- Malignant Neoplasm Of Lung
- Malignant Neoplasm Of Ovary
- Mammary Neoplasms
Interacting Proteins
- ASPSCR1
- CIB3
- CKAP5
- CLTA
- KIZ
- SNX20
- TBC1D22B
- VPS37C
Pathways
- Cell Cycle
- Mitosis
- Localization
- Spindle Assembly
- Cell Division
- Chromosome Segregation
- Cell Death
- Translation
- Cell Growth
- Rna Interference
- Cytokinesis
- Cell Proliferation
- Circadian Rhythm
PTMs
- Phosphorylation
- Methylation
Research Areas
- Apoptosis
- Cancer
- Mitotic Regulators
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TACC3
bosterbio.com/bosterbio-gene-info-cards/TACC3
References
PMID: 10366448 by Still I.H., et al. The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines.
PMID: 11298601 by McKeveney P.J., et al. Characterization and localization of expression of an erythropoietin- induced gene, ERIC-1/TACC3, identified in erythroid precursor cells.