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SREBF1 Antibodies
AND SREBF1 ELISA kits, SREBF1 Proteins
Many biological assays use antibodies to detect SREBF1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SREBF1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SREBF1 antibodies...
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SREBF1 Infographic by Boster Bio
All SREBF1 Products
Product
Figures
Specificity
Applications
Price
Human, Rat
ELISA
$480
Cat # EKC1538
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1538
1 kit, containing one 96-well plate and all necessary reagents
Human, Rat
ELISA
$540
Cat # EKC2626
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2626
1 kit, containing two 96-well plates and all necessary reagents
SREBF1 Overview
Facts about Sterol regulatory element-binding protein 1.
Sterol regulatory element-binding protein 1 (SREBF1)
Transcriptional activator necessary for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity).
Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box theme (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').
Gene Information
| Human | |
|---|---|
| Gene Name: | SREBF1 |
| Uniprot: | P36956 |
| Entrez: | 6720 |
Family
| Belongs to: |
|---|
| SREBP family |
Alternative Names
BHLHD1; Class D basic helix-loop-helix protein 1; SREBP 1c; SREBP-1; SREBP1bHLHd1SREBP-1c; sterol regulatory element binding protein-1; sterol regulatory element binding transcription factor 1; sterol regulatory element-binding protein 1; Sterol regulatory element-binding transcription factor 1
Molecular Weight
Mass (kDA):
121.675 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p11.2 |
| Sequence: | 17; NC_000017.11 (17811334..17837017, complement) |
Tissue Specificity
Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle.
Subcellular Localizations
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.; [Processed sterol regulatory element-binding protein 1]: Nucleus.; [Isoform SREBP-1aDelta]: Nucleus.; [Isoform SREBP-1cDelta]: Nucleus.
Diseases
- Obesity
- Insulin Resistance
- Fatty Liver
- Diabetes Mellitus
- Steatosis
- Diabetes Mellitus, Non-insulin-dependent
- Steatohepatitis
- Malignant Neoplasms
- Liver Carcinoma
- Hyperlipidemia
- Insulin Sensitivity
- Atherosclerosis
- Liver Diseases
Interacting Proteins
- CREBBP
- MED15
- SIRT1
Pathways
- Secretion
- Cholesterol Homeostasis
- Transport
- Pathogenesis
- Fatty Acid Oxidation
- Lipid Homeostasis
- Proteolysis
- Localization
- Cell Death
- Cholesterol Efflux
- Insulin Secretion
- Cell Proliferation
- Gluconeogenesis
PTMs
- Cleavage
- Phosphorylation
- Oxidation
- Acetylation
- Ubiquitination
- Reduction
- Sumoylation
- Hydroxylation
- Dephosphorylation
Research Areas
- Cancer
- Cholesterol Metabolism
- Chromatin Research
- Diabetes Research
- Lipid and Metabolism
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SREBF1
bosterbio.com/bosterbio-gene-info-cards/SREBF1
References
PMID: 8402897 by Yokoyama C., et al. SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene.
PMID: 7759101 by Hua X., et al. Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13.