Slc46a1 Antibodies

AND Slc46a1 ELISA kits, Slc46a1 Proteins

Many biological assays use antibodies to detect Slc46a1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Slc46a1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Slc46a1 antibodies...

We validate the specificity of these antibodies to Slc46a1 by testing them on tissues known to express Slc46a1 positively and negatively. Browse below to find the Slc46a1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Slc46a1 Infographic by Boster Bio

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HCP1 (SLC46A1) (NM_080669) Human Over-expression Lysate

Human

$960
Cat # LS113235
100 µg

Slc46a1 Overview

Facts about Proton-coupled folate transporter.

Proton-coupled folate transporter (Slc46a1)

Has been shown to act both as an intestinal proton- coupled high-affinity folate transporter and as an intestinal heme transporter that mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and could be transported into the bloodstream.

Dietary heme iron is also an important nutritional source of iron. Shows a greater affinity for folate compared to heme.

Gene Information

Mouse
Gene Name:	Slc46a1
Uniprot:	Q6PEM8
Entrez:	52466

Family

Belongs to:

major facilitator superfamily

Alternative Names

FLJ39875; G21; HCP1PCFT/HCP1; Heme carrier protein 1; MGC9564; PCFTsolute carrier family 46, member 1; proton-coupled folate transporter; solute carrier family 46 (folate transporter), member 1; Solute carrier family 46 member 1

Molecular Weight

Mass (kDA):
50.089 kDA

Genomic Context


Mouse

Location:	11 B5\|11 46.74 cM
Sequence:	11;

Tissue Specificity

Highly expressed in duodenum, especially in duodenal mucosa, the main site of intestinal heme absorption. Weakly expressed in the kidney. Not expressed in duodenum before weaning or in placenta. Weakly or not expressed in brain, heart, lung, skeletal muscle, testis and neonatal liver.

Diseases

Malabsorption Syndrome
Congenital Defect Of Folate Absorption
Folic Acid Deficiency
Neoplasms
Anemia
Malignant Neoplasms
Nervousness
5,10-methylenetetrahydrofolate Reductase Deficiency
Hemochromatosis
Inborn Errors Of Metabolism
Iron Overload
Carcinoma

Hypoxia
Immunologic Deficiency Syndromes
Cytomegalovirus Infections
Severe Combined Immunodeficiency
Rheumatoid Arthritis
Liver Carcinoma
Arthritis

Pathways

Transport
Intestinal Absorption
Localization
Methylation
Heme Transport
Endocytosis
Receptor-mediated Endocytosis
Proton Transport
Cellular Homeostasis
Glycosylation
Response To Vitamin
Blood Circulation
Response To Vitamin D

Macrophage Activation
Demethylation
Drug Resistance
Microtubule Depolymerization
Translation
Drug Transport
Protein Digestion

PTMs

Methylation
Demethylation

Carboxylation
Biotinylation

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Slc46a1

References

PMID: 16143108 by Shayeghi M., et al. Identification of an intestinal heme transporter.