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Slc27a1 Antibodies
AND Slc27a1 ELISA kits, Slc27a1 Proteins
Many biological assays use antibodies to detect Slc27a1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Slc27a1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Slc27a1 antibodies...
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Slc27a1 Overview
Facts about Long-chain fatty acid transport protein 1.
Long-chain fatty acid transport protein 1 (Slc27a1)
Mediates the ATP-dependent import of long-chain fatty acids (LCFA) to the cell by mediating their translocation in the plasma membrane (PubMed:7954810, PubMed:9786857, PubMed:9671728, PubMed:10471110, PubMed:12235169, PubMed:11970897, PubMed:15699031, PubMed:28178239). Additionally, it an acyl-CoA ligase action for jelqing and very-long-chain fatty acids (PubMed:10593920, PubMed:12235169, PubMed:12937175).
May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation (PubMed:14991074, PubMed:15897321). Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues experiencing high levels of beta-oxidation or triglyceride synthesis (PubMed:12235169).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Slc27a1 |
| Uniprot: | Q60714 |
| Entrez: | 26457 |
Family
| Belongs to: |
|---|
| ATP-dependent AMP-binding enzyme family |
Alternative Names
ACSVL5FATP-1; EC 6.2.1; EC 6.2.1.-; FATP1; FATP1Solute carrier family 27 member 1; FATPlong-chain fatty acid transport protein 1; Fatty acid transport protein 1; FLJ00336; MGC71751; SLC27A1; solute carrier family 27 (fatty acid transporter), member 1
Molecular Weight
Mass (kDA):
71.276 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 8|8 B3.3 |
| Sequence: | 8; |
Tissue Specificity
Highest expression in skeletal muscle, heart and fat. Lower levels in brain, kidney, lung, liver and testis. No expression in spleen or intestine.
Diseases
- Obesity
- Insulin Resistance
- Diabetes Mellitus
- Insulin Sensitivity
- Cardiomyopathies
- Hyperlipidemia
- Diabetes Mellitus, Non-insulin-dependent
- Impaired Glucose Tolerance
- Heart Failure
- Hyperinsulinism
- Metabolic Syndrome X
- Metabolic Diseases
Pathways
- Transport
- Fatty Acid Transport
- Localization
- Fatty Acid Oxidation
- Pathogenesis
- Energy Homeostasis
- Lipid Oxidation
- Oxidative Phosphorylation
- Glucose Homeostasis
- Lipid Homeostasis
- Insulin Secretion
- Secretion
- Cell Adhesion
PTMs
- Oxidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Slc27a1
bosterbio.com/bosterbio-gene-info-cards/Slc27a1
References
PMID: 7954810 by Schaffer J.E., et al. Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein.
PMID: 9765271 by Hui T.Y., et al. Characterization of the murine fatty acid transport protein gene and its insulin response sequence.