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Sik1 Antibodies
AND Sik1 ELISA kits, Sik1 Proteins
Many biological assays use antibodies to detect Sik1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sik1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sik1 antibodies...
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Sik1 Overview
Facts about Serine/threonine-protein kinase SIK1.
Serine/threonine-protein kinase SIK1 (Sik1)
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2.
Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a sort of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to lack of adhesion and can suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: subsequent increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Sik1 |
| Uniprot: | Q60670 |
| Entrez: | 17691 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11; EC 2.7.11.1; msk; myocardial SNF1-like kinase; salt-inducible kinase 1; Salt-inducible protein kinase 1; serine/threonine protein kinase; serine/threonine-protein kinase SIK1; Serine/threonine-protein kinase SNF1-like kinase 1; Serine/threonine-protein kinase SNF1LK; SIK; SIK-1; SNF1-like kinase; SNF1LKMSK
Molecular Weight
Mass (kDA):
85.115 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 17 B1|17 17.25 cM |
| Sequence: | 17; |
Tissue Specificity
Expressed in lung, skin, ovary, heart and stomach. No expression in brain, liver or adult skeletal muscle but is present in skeletal muscle progenitor cells of the somite beginning at 9.5 dpc. Present at 8.0 dpc in the monolayer of presumptive myocardial cells but rapidly down-regulated at 8.5 dpc upon primitive ventricle formation, although still present in myocardial cells that will populate the primitive atrium and bulbus cordis. At 9.5 dpc expression is down-regulated in the primitive atrium but observed in the sinus venosus and truncus arteriosus.
Diseases
- Neoplasms
- Tumors Of Adrenal Cortex
- Hypertensive Disease
- Insulin Resistance
- Neoplasm Metastasis
- Essential Hypertension
- Malignant Neoplasms
- Lymphoma
- Mammary Neoplasms
- Diabetes Mellitus
- Diffuse Large B-cell Lymphoma
- Edema
- B-cell Lymphomas
Pathways
- Localization
- Transport
- Cell Cycle
- Nuclear Export
- Cell Growth
- Rrna Processing
- Cell Division
- Cell Differentiation
- Methylation
- Anoikis
- Gluconeogenesis
- Regulation Of Dephosphorylation
- M Phase
PTMs
- Phosphorylation
- Dephosphorylation
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Sik1
bosterbio.com/bosterbio-gene-info-cards/Sik1
References
PMID: 7893599 by Ruiz J.C., et al. Identification of novel protein kinases expressed in the myocardium of the developing mouse heart.
PMID: 12200423 by Takemori H., et al. ACTH-induced nucleocytoplasmic translocation of salt-inducible kinase. Implication in the protein kinase A-activated gene transcription in mouse adrenocortical tumor cells.