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Sialoadhesin Antibodies
AND SIGLEC1 ELISA kits, Sialoadhesin Proteins
Many biological assays use antibodies to detect Sialoadhesin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sialoadhesin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sialoadhesin antibodies...
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SIGLEC1 Infographic by Boster Bio
All SIGLEC1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$750
Cat # EK1304
96 wells/kit, with removable strips.
Cat # EK1304
96 wells/kit, with removable strips.
Mouse
ELISA
$750
Cat # EK1305
96 wells/kit, with removable strips.
Cat # EK1305
96 wells/kit, with removable strips.
Human
Flow Cytometry, IP, IHC-F, WB
$299
Cat # M05186
0.1 mg
Cat # M05186
0.1 mg
Human
ELISA
$499
Cat # FEK1304
96 wells/kit, with removable strips.
Cat # FEK1304
96 wells/kit, with removable strips.
SIGLEC1 Overview
Facts about Sialoadhesin.
Sialoadhesin (SIGLEC1)
Acts as an endocytic receptor exerts clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells.
Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | SIGLEC1 |
| Uniprot: | Q9BZZ2 |
| Entrez: | 6614 |
Family
| Belongs to: |
|---|
| immunoglobulin superfamily |
Alternative Names
CD169; FLJ00051; sialic acid binding Ig-like lectin 1, sialoadhesin; sialoadhesin; Siglec1; Siglec-1
Molecular Weight
Mass (kDA):
182.624 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20p13 |
| Sequence: | 20; NC_000020.11 (3686970..3712600, complement) |
Tissue Specificity
Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis.
Subcellular Localizations
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
Diseases
- Tissue Adhesions
- Inflammation
- Neoplasms
- Porcine Reproductive And Respiratory Syndrome
- Sclerosis
- Autoimmune Reaction
- Malignant Neoplasms
- Lymphoma
- Cell Invasion
- Malaria
- Neoplasm Metastasis
- Carcinoma
- Autoimmune Diseases
Pathways
- Cell Adhesion
- Pathogenesis
- Immune Response
- Phagocytosis
- Localization
- Cell Activation
- Endocytosis
- Glycosylation
- Cytokine Production
- Secretion
- Osteoclast Differentiation
- T Cell Activation
- Tropism
PTMs
- Glycosylation
Research Areas
- Adaptive Immunity
- Immunology
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SIGLEC1
bosterbio.com/bosterbio-gene-info-cards/SIGLEC1
References
PMID: 11133773 by Hartnell A., et al. Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations.
PMID: 11214971 by Hattori A., et al. Characterization of long cDNA clones from human adult spleen.