SH2B adapter protein 1 Antibodies

AND Sh2b1 ELISA kits, SH2B adapter protein 1 Proteins

Many biological assays use antibodies to detect SH2B adapter protein 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SH2B adapter protein 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SH2B adapter protein 1 antibodies...

We validate the specificity of these antibodies to SH2B adapter protein 1 by testing them on tissues known to express Sh2b1 positively and negatively. Browse below to find the Sh2b1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Sh2b1 Infographic by Boster Bio

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Sh2b1 Overview

Facts about SH2B adapter protein 1.

SH2B adapter protein 1 (Sh2b1)

Adapter protein for several members of the tyrosine kinase receptor family. Involved in several signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, such as the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs).

In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form possible binding sites for other signaling proteins.

Gene Information

Mouse
Gene Name:	Sh2b1
Uniprot:	Q91ZM2
Entrez:	20399

Family

Belongs to:

SH2B adapter family

Alternative Names

FLJ30542; KIAA1299; Pro-rich, PH and SH2 domain-containing signaling mediator; PSM; SH2 domain-containing protein 1B; SH2 domain-containing putative adapter SH2-B; SH2B adapter protein 1; SH2B adaptor protein 1; SH2-B signaling protein; SH2B1; SH2BDKFZp547G1110

Molecular Weight

Mass (kDA):
79.625 kDA

Genomic Context


Mouse

Location:	7 F3\|7 69.06 cM
Sequence:	7;

Tissue Specificity

Widely expressed with highest levels in liver, brain and heart. Isoform 3 is widely expressed.

Diseases

Obesity
Diabetes Mellitus
Diabetes Mellitus, Non-insulin-dependent
Janiceps
Insulin Resistance
Polyendocrinopathies, Autoimmune
Nervousness
Malignant Neoplasms
Insulin Sensitivity
Impaired Glucose Tolerance
Hyperphagia
Tissue Adhesions

Cardiovascular Diseases
Developmental Delay (disorder)
Infertility
Neoplasms
Autistic Disorder
Pediatric Obesity

Pathways

Glucose Homeostasis
Cell Motility
Localization
Cell Adhesion
Cell Proliferation
Cell Migration
Aging
Cell Growth
Pathogenesis
Transport
Cell Activation
T Cell Activation
Nuclear Export

Cell Cycle Arrest
Flight
Cytoskeleton Organization
Sensitization
Mrna Splicing
Cell Cycle
Feeding Behavior

PTMs

Phosphorylation

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Sh2b1

References

PMID: 9498552 by Riedel H., et al. PSM, an insulin-dependent, pro-rich, PH, SH2 domain containing partner of the insulin receptor.

PMID: 10594240 by Nelms K., et al. Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain.