Serine incorporator 3 Antibodies

Serine incorporator 3 (SERINC3)

Restriction factor needed to restrict infectivity of lentiviruses, such as HIV-1: functions by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734).

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Gene Information

Human
Gene Name:	SERINC3
Uniprot:	Q13530
Entrez:	10955

Family

Belongs to:
TDE1 family

Alternative Names

AIGP1; DIFF33tumor differentially expressed 1; placental transmembrane protein (mouse testicular tumor differentiallyexpressed); SBBI99; serine incorporator 3; TDE; TDE1Tumor differentially expressed protein 1; TMS-1; transmembrane protein SBBI99; tumour differentially expressed 1

Molecular Weight

Mass (kDA):
52.58 kDA

Genomic Context

Human
Location:	20q13.12
Sequence:	20; NC_000020.11 (44496221..44522116, complement)

Tissue Specificity

Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.; Cytoplasm, perinuclear region. (Microbial infection) Upon HIV-1 infection, it is redirected to perinuclear region following interaction with HIV-1 Nef, excluding it from virions particles, thereby preventing subsequent antiviral defense activity (Probable).

Diseases

• Neoplasms
• Cell Transformation, Neoplastic
• Testicular Neoplasms
• Malignant Neoplasms
• Colorectal Neoplasms

Pathways

• Localization
• Reverse Transcription
• Programmed Cell Death
• Cell Death
• Cell Differentiation
• Glycosylation
• Contact Inhibition

• Oncogenesis

PTMs

• Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SERINC3

Boster Bio: Best Uses of the SERINC3 Marker

If you're a scientist and want to know more about the Boster Bio: Best Uses of the SERINC3 marker, you've come to the right place. Here you'll learn about Steven Boster's background, high-affinity antibodies, and the SERINC3 marker. You'll also discover how the SERINC3 marker can help you in your research.

His high-affinity antibodies

The affinity of His high-affinity antibodies is a measurement of how well the antibody can bind to the SERINC3 protein. It is calculated by comparing the rates at which the antibody can associate with the target protein and dissociate from it. In a typical assay, antibodies with high affinity to His will have lower KD values. The data were collected at UC Davis and reviewed by scientists at Abcam.

These antibodies are highly specific because they recognize the SERINC3 marker. This is important for early detection and monitoring of the success of treatment. However, mAbs are not ideal high-affinity probes because of their weak tumor penetration and long serum half-life. Furthermore, they produce low contrast images due to their high serum half-life. The solution to these problems is to create smaller antibody fragments that target his high-affinity proteins.

Although direct screening of phages after panning is sufficient for the selection of binders, careful screening is needed for the development of specific His antibodies. This is made possible by mass-transfer of enriched VHHs into expression vectors. Mass-transfer of VHHs results in different antibody constructs. Another useful modification is the metabolic addition of biotin. Biotin is covalently attached to a Lys residue and overexpressed in the production of Nb.

Single-chain variable domains and heavy-chain variable fragments are engineered antibodies with superior chemical properties. These antibodies are smaller and easier to manufacture than conventional antibodies and retain the targeting specificity of the entire antibody. These modified antibodies can also be produced at lower cost and can be used in diagnostics. They have superior chemical properties, solubility, and stability of the whole Ig molecule.

SERINC3 marker

SERINC3 is a novel protein marker used in the analysis of proteins. In the past, it was difficult to determine which proteins were responsible for producing the protein. Fortunately, Boster has made the process much simpler with its SERINC3 ELISA kit. This versatile tool helps researchers to determine whether or not proteins are involved in certain disease processes. In this article, we will look at the best uses of SERINC3 and discuss why they are important for researchers.