SCARB1 Antibodies

Scavenger receptor class B member 1 (SCARB1)

Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579). Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621).

Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218).

Gene Information

Human
Gene Name:	SCARB1
Uniprot:	Q8WTV0
Entrez:	949

Family

Belongs to:
CD36 family

Alternative Names

CD36 and LIMPII analogous 1; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; CD36 antigen; CD36L1; CD36L1scavenger receptor class B type 1; CLA1 CD36 antigen-like 1; CLA-1 HDLQTL6; CLA1; Collagen type I receptor, thrombospondin receptor-like 1; HDLQTL6; MGC138242; SCARB1; scavenger receptor class B type III; scavenger receptor class B, member 1; SRB1 scavenger receptor class B member 1; SR-B1; SRBI; SR-BI

Molecular Weight

Mass (kDA):
60.878 kDA

Genomic Context

Human
Location:	12q24.31
Sequence:	12; NC_000012.12 (124776856..124863864, complement)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein. Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.

Diseases

• Atherosclerosis
• Arteriosclerosis
• Tissue Adhesions
• Inflammation
• Hepatitis
• Hepatitis C
• Cardiovascular Diseases
• Liver Carcinoma
• Hypercholesterolemia
• Diabetes Mellitus
• Coronary Artery Disease
• Alzheimer's Disease

• Heart Diseases
• Coronary Heart Disease
• Dental Plaque
• Neoplasms
• Malignant Neoplasms
• Myocardial Infarction
• Diabetes Mellitus, Non-insulin-dependent

Interacting Proteins

• KRTAP10-9
• KRTAP5-9
• PLCG1

Pathways

• Transport
• Cholesterol Transport
• Cholesterol Efflux
• Reverse Cholesterol Transport
• Secretion
• Endocytosis
• Cholesterol Homeostasis
• Pathogenesis
• Phagocytosis
• Localization
• Excretion
• Lipid Transport
• Receptor-mediated Endocytosis

• Inflammatory Response
• Cell Adhesion
• Intestinal Cholesterol Absorption
• Intestinal Absorption
• Cholesterol Esterification
• Immune Response
• Cell Death

PTMs

• Acetylation
• Phosphorylation
• Oxidation
• Cleavage
• Glycosylation
• Phosphorothioation
• Acylation
• Biotinylation
• Ubiquitination

• Iodination
• Nitration
• Reduction
• Carboxylation
• Hydroxylation
• Dephosphorylation
• Farnesylation
• Methylation
• Palmitoylation

• Deglycosylation

Research Areas

• Breast Cancer
• Cancer
• Cholesterol Metabolism
• Lipid and Metabolism
• Signal Transduction

• Virology, Bacteria and Parasites

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SCARB1

Boster Bio - Best Uses Of The SCARB1 Marker

Boster Bio is your best option for a SCARB1-antibody. Boster Bio's SCARB1 anti-body is effective on all species. You can also submit your results to receive product credits. This guide is designed for researchers from all over the world. Continue reading to learn more about BosterBio and SCARB1 anti-inflammatory optimization. We hope you find it useful!

Boster Bio

The SCARB1 marker has been identified as a biomarker that is essential to detect apoptosis-related gene, the PPARg. It is an essential apolipoprotein found in HDL and plays important roles in controlling cholesterol efflux and forming new HDL particles. It is abundantly found in human tissues, and has numerous anti-inflammatory and antioxidant properties. However it is associated with the oxidative stress that results in functional impairment. It is found in atherosclerotic plaque, and is extremely prevalent in patients suffering from coronary artery disease.

Anti-SCARB1 Antibody

Boster Bio Anti-SCARB1 Antibody has been approved for use in ELISA and IF as well as IHC and WB. It reacts with Human and is made against synthetic peptides containing 15 amino acids. This antibody binds with the SCARB amino acids 70-120. To maximize effectiveness, a blocking peptide can be purchased in a specific length of immunogen.

Xbp1-s

The transcription factor XBP1-s that plays a crucial role in the unfolded response (UPR). It is transcribed from unspliced mRNA through the activated stress sensor IRE1a and then transforms into a mature form encoding the spliced XBP1s. This protein then moves into the nucleus, where it controls the transcription of several genes.

XBP1-s regulates transcription in targeted genes in a variety of cells and tissues. Their targets include genes involved in the metabolism of proteins and lipids as well as immune responses and the development of cancer. The development of secretory cells could be affected by the genes that XBP1-1-s regulate. Hence, XBP1-s are an option for therapeutic targets in patients suffering from dyslipidemia.

The XBP1s target genes in the immune response, cell cycle and cell proliferation. They inhibit Th2 cell proliferation and block Th2 cytokines' expression. Thus, XBP1-s is crucial to the proper development of Th2 cells. Its phosphorylation reduces the activity of a variety of genes that are involved in the immune system. Boster Bio's XBP1s are essential for immune response and are required for the body to maintain its natural defense mechanism.

A newly discovered gene, XBP1U, is essential in the regulation of the MDM2/p53 axis. It plays a crucial role in the process of cell cycle and tumorigenesis. It also plays a role in senescence and embryogenesis. These findings provide a new understanding into the role of the MDM2/p53 axis. It also has wide-ranging implications on the immune system.

XBP1 plays a crucial role in the regulation of glucose homeostasis. It also aids in the multimerization process of adiponectin inside adipocytes. The XBP1s are closely linked to the treatment and prevention of obesity as well as type 2 diabetes arthritis, and other conditions. They also enhance the activity of several ER chaperones that are involved in the maturation of adiponectin. These effects could improve the sensitivity to insulin and glucose tolerance.

Many of the physiological and pathological processes are influenced or influenced by XBP1-s. In addition to regulating immune system responses, they play a crucial role in inflammatory conditions such as cancer. This is why these proteins are being considered as therapeutic targets for cancer. However further research must be conducted to better comprehend their role in the tumor-infiltrating immune response. If you're curious about what these genes do you can read more about XBP1-s and its functions in Boster Bio.

Xbp1-s optimization

The optimization of XBP1's expression in cancer cells could enhance the treatment options. These tumors are more tolerant of XBP1 than normal breast tissue. XBP1 increase in expression can cause an increase in tumor size and the sensitivity. The protein regulates tumorigenesis through stimulating plasma cell differentiation and death rates, reducing the number of cells and triggering drug resistance. In addition, XBP1 interacts with numerous signaling pathways that influence cell survival, growth, and proliferation.

We first analyzed cDNA for hamster Xbp1 expression using a complete RNA from CHO cells and tunicamycin-treated CHO cells. Then, we used regular RT-PCR to determine Xbp1 MRNA. A primer set was constructed that was based on the partial DNA sequence haXbp1F as well as haXbp1R. The RNAs were separated using 3% of agarose gels.

The overexpression of XBP1-s is linked with a larger ER network. This is due in part to its role in secretory pathways. The overexpression of XBP1-s increases the activity of the dimphosphocholine pathway cytidine that is necessary for the biosynthesis of phosphatidcholine. XBP1-1-s stimulates ER biogenesis by increasing secretory pathway activity.

The XBP1 gene is a conserved transcription factor that binds to CRE elements and other target genes. These binding sites typically are within 200 bp of transcriptional starting sites, which allows XBP1 to activate various oncogenic signaling pathways. This is good news for biomedical research. What can we do to optimize XBP1 expression in cancer cells?

Finding new MIST1 gene targets is an important step in optimizing XBP1 expression within cancer cells. MIST1 regulates XBP1 through feedback mechanisms. It also acts as a regulator of secretory pathways, and the UPR pathway. Both XBP1 and MIST1 are responsible for the regulation of complex networks of genes that contribute to normal secretory function.

The XBP1 gene is believed to regulate cancer growth and invasion. Boster Bio Anti XBP1 antibody recognizes Human and Mouse and binds to XBP1 in all three cells. It can be used in conjunction with various cell types and stored at -20°C for up to one year. Each vial contains 5 mg of BSA and 0.05mg NaN3. This antibody is created from the human XBP1 peptide sequence. A blocking peptide may be purchased separately.