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SUV39H1 Antibodies
AND SUV39H1 ELISA kits, SUV39H1 Proteins
Many biological assays use antibodies to detect SUV39H1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SUV39H1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SUV39H1 antibodies...
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SUV39H1 Overview
Facts about Histone-lysine N-methyltransferase SUV39H1.
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1)
Histone methyltransferase that especially trimethylates'Lys-9' of histone H3 with monomethylated H3'Lys- 9' as substrate. Also weakly methylates histone H1 (in vitro).
H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.
Gene Information
| Human | |
|---|---|
| Gene Name: | SUV39H1 |
| Uniprot: | O43463 |
| Entrez: | 6839 |
Family
| Belongs to: |
|---|
| class V-like SAM-binding methyltransferase superfamily |
Alternative Names
H3-K9-HMTase 1; Histone H3-K9 methyltransferase 1; histone-lysine N-methyltransferase SUV39H1; histone-lysine N-methyltransferase, H3 lysine-9 specific 1; KMT1AEC 2.1.1.43; Lysine N-methyltransferase 1A; MG44; Position-effect variegation 3-9 homolog; Su(var)3-9 homolog 1; suppressor of variegation 3-9 (Drosophila) homolog 1; suppressor of variegation 3-9 homolog 1 (Drosophila); Suppressor of variegation 3-9 homolog 1; Suppressor of variegation 3-9 homolog 1, Suvar) 3-9 homolog; SUV39H
Molecular Weight
Mass (kDA):
47.907 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xp11.23 |
| Sequence: | X; NC_000023.11 (48695554..48709016) |
Subcellular Localizations
Nucleus. Nucleus lamina. Nucleus, nucleoplasm. Chromosome, centromere. Associates with centromeric constitutive heterochromatin.
Diseases
- Neoplasms
- Malignant Neoplasms
- Leukemia
- Retinoblastoma
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
- Tumor Progression
- Leukemogenesis
- Carcinoma
- Myeloid Leukemia
- Mammary Neoplasms
- Lymphoma
Interacting Proteins
- ATE1
- BCL11B
- C8orf74
- CBX1
- CBX3
- CBX5
- CCDC151
- CDCA4
- CEP70
- CLK3
Pathways
- Methylation
- Histone Methylation
- Dna Methylation
- Gene Silencing
- Cell Cycle
- Localization
- Histone Acetylation
- Histone Modification
- Histone Deacetylation
- Chromatin Remodeling
- Mitosis
- Pathogenesis
- Senescence
PTMs
- Methylation
- Acetylation
- Deacetylation
- Phosphorylation
- Demethylation
- Sumoylation
Research Areas
- Cell Cycle and Replication
- Chromatin Research
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SUV39H1
bosterbio.com/bosterbio-gene-info-cards/SUV39H1
References
PMID: 10202156 by Aagaard L., et al. Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31.
PMID: 10671371 by Aagaard L., et al. Mitotic phosphorylation of SUV39H1, a novel component of active centromeres, coincides with transient accumulation at mammalian centromeres.