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- Table of Contents
Facts about Transcription elongation factor SPT4.
DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the meeting of an elongation competent RNA polymerase II complex.
Human | |
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Gene Name: | SUPT4H1 |
Uniprot: | P63272 |
Entrez: | 6827 |
Belongs to: |
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SPT4 family |
DRB sensitivity-inducing factor 14 kDa subunit; DRB sensitivity-inducing factor small subunit; DSIF p14; DSIF small subunit; SPT4; SPT4HhSPT4; suppressor of Ty (S.cerevisiae) 4 homolog 1; suppressor of Ty 4 homolog 1 (S. cerevisiae); SUPT4H; transcription elongation factor SPT4
Mass (kDA):
13.193 kDA
Human | |
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Location: | 17q22 |
Sequence: | 17; NC_000017.11 (58345178..58352201, complement) |
Widely expressed.
Nucleus.
PMID: 8786137 by Chiang P.-W., et al. Isolation and characterization of the human and mouse homologues (SUPT4H and Supt4h) of the yeast SPT4 gene.
PMID: 8649394 by Hartzog G.A., et al. Identification and analysis of a functional human homolog of the SPT4 gene of Saccharomyces cerevisiae.