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- Table of Contents
Facts about Suppressor of fused homolog.
Section of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 into BTRC and thereby targeting GLI1 to degradation by the proteasome.
Mouse | |
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Gene Name: | Sufu |
Uniprot: | Q9Z0P7 |
Entrez: | 24069 |
Belongs to: |
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SUFU family |
SUFUHSUFUXLPRO1280; suppressor of fused homolog (Drosophila); suppressor of fused homolog
Mass (kDA):
53.957 kDA
Mouse | |
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Location: | 19 C3|19 38.85 cM |
Sequence: | 19; |
Widely expressed in adult and fetal tissues.
PMID: 10531011 by Ding Q., et al. Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1.
PMID: 11252182 by Delattre M., et al. Suppressor of fused gene involved in hedgehog signal transduction in Drosophila melanogaster is conserved in mammals.