Sufu Antibodies

Suppressor of fused homolog (Sufu)

Negative regulator in the hedgehog/smoothened signaling pathway (PubMed:16155214, PubMed:16459298). Down-regulates GLI1- mediated transactivation of target genes.

Section of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 into BTRC and thereby targeting GLI1 to degradation by the proteasome.

Gene Information

Mouse
Gene Name:	Sufu
Uniprot:	Q9Z0P7
Entrez:	24069

Family

Belongs to:
SUFU family

Alternative Names

SUFUHSUFUXLPRO1280; suppressor of fused homolog (Drosophila); suppressor of fused homolog

Molecular Weight

Mass (kDA):
53.957 kDA

Genomic Context

Mouse
Location:	19 C3|19 38.85 cM
Sequence:	19;

Tissue Specificity

Widely expressed in adult and fetal tissues.

Diseases

• Malignant Neoplasms
• Neoplasms
• Medulloblastoma
• Carcinoma
• Basal Cell Carcinoma
• Cell Transformation, Neoplastic
• Cerebellar Neoplasms
• Carcinogenesis
• Brain Neoplasms
• Basal Cell Nevus Syndrome
• Malignant Neoplasm Of Stomach
• Desmoplastic
• Malignant Paraganglionic Neoplasm

• Leukemia
• Adenocarcinoma
• Malignant Neoplasm Of Prostate
• Rhabdomyosarcoma
• Esophageal Neoplasms
• Malignant Neoplasm Of Pancreas
• Skin Neoplasms

Pathways

• Localization
• Fermentation
• Pathogenesis
• Cell Proliferation
• Tissue Homeostasis
• Aging
• Nuclear Export
• Cell Growth
• Cell Differentiation
• Cell Cycle
• Nuclear Import
• Sex Determination
• Limb Development

• Spermatogenesis
• Intraflagellar Transport
• Spinal Cord Patterning
• Transport
• Proteolysis
• Cell Fate Determination
• Neurogenesis

PTMs

• Phosphorylation
• Cleavage
• Methylation

• Ubiquitination
• Reduction
• Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Sufu

Best Uses Of The SUFU Marker

If you have been interested in using the SUFU Marker, you've probably been wondering what its best uses are. To get the most out of it, read on for some answers to the most frequently asked questions. And remember, if you want to use the SUFU Marker in your classroom, always link or cite the source! There are several ways to get started.

SUFU Marker

The SUFU marker is a protein that regulates the Shh pathway and leads to massive degradation of proteins. In mammals, this process is known as proteasome-dependent proteolytic cleavage. In a mouse model, it has been linked to tumorigenesis. Overexpression of this gene is associated withIn high level of stromal invasion, FIGO stage, and lymph node metastasis.

One study examined the clinical significance of overexpression of Sufu in cervical cancer. In addition to affecting proliferation, overexpression of the gene was also associated withIvarious clinical characteristics, including FIGO stage, depthIof stromal invasion, and vascular cancer embolus. In further studies, the protein may represent a new diagnostic marker or therapeutic target in cervical cancer. This is promising news for cervical cancer patients.