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- Table of Contents
Facts about Syntaxin-1A.
May mediate Ca(2+)- regulation of exocytosis acrosomal reaction in sperm. .
Human | |
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Gene Name: | STX1A |
Uniprot: | Q16623 |
Entrez: | 6804 |
Belongs to: |
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syntaxin family |
Brain Syntaxin; HPC-1; Neuron-specific antigen HPC-1; p35-1; STX1A; STX1P35-1; SYN1A; syntaxin 1A (brain); Syntaxin 1A; syntaxin-1A
Mass (kDA):
33.023 kDA
Human | |
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Location: | 7q11.23 |
Sequence: | 7; NC_000007.14 (73699210..73719673, complement) |
Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain.
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome. Cell membrane. Colocalizes with KCNB1 at the cell membrane.; [Isoform 2]: Secreted.
PMID: 7622072 by Zhang R.-D., et al. Cloning and sequence analysis of a cDNA encoding human syntaxin 1A, a polypeptide essential for exocytosis.
PMID: 9311751 by Osborne L.R., et al. Hemizygous deletion of the syntaxin 1A gene in individuals with Williams syndrome.