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Stra6 Antibodies
AND Stra6 ELISA kits, Stra6 Proteins
Many biological assays use antibodies to detect Stra6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Stra6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Stra6 antibodies...
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Stra6 Overview
Facts about Receptor for retinol uptake STRA6.
Receptor for retinol uptake STRA6 (Stra6)
Functions as retinol transporter (PubMed:23839944, PubMed:24852372). Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport throughout the cell membrane, and then transports retinol to the cytoplasmic retinol-binding protein RBP1.
Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A (By similarity). Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent production of retinol metabolites that then trigger activation of JAK2 and its goal STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin (PubMed:21368206, PubMed:23839944).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Stra6 |
| Uniprot: | O70491 |
| Entrez: | 20897 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
FLJ12541; MCOPS9; stimulated by retinoic acid gene 6 homolog (mouse); stimulated by retinoic acid gene 6 protein homolog; STRA6
Molecular Weight
Mass (kDA):
73.775 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 9|9 B |
| Sequence: | 9; |
Tissue Specificity
Widely expressed in the embryo (PubMed:9203140, PubMed:23839944). Detected in adult in the retinal pigment epithelium in the eye (PubMed:9203140, PubMed:22467576, PubMed:23839944, PubMed:24852372). In the adult, is highly expressed in cells that compose blood-organ barriers in the brain (choroid plexus and the brain microvascular), in testis (the basal layer of the seminiferous epithelium), in the yolk sac, and in the chorioallantoic placenta (PubMed:9203140, PubMed:23839944). Detected in white adipose tissue and skeletal muscle, but not in liver (at protein level) (PubMed:21368206). Widely expressed in adult, with high expression levels in the eye (PubMed:24852372). Detected in brain, cerebellum, testis, pituitary, pancreas, kidney, spleen, and female genital tract; and at very low levels in heart and lung (PubMed:9203140, PubMed:24852372). Not detected in liver (PubMed:9203140).
Diseases
- Anophthalmos
- Anophthalmia And Pulmonary Hypoplasia
- Congenital Abnormality
- Vitamin A Deficiency
- Diaphragmatic Hernia
- Microphthalmos
- Hernia
- Malignant Neoplasms
- Insulin Resistance
- Hypoplasia
- Embryonal Carcinoma
- Obesity
Pathways
- Transport
- Pathogenesis
- Eye Development
- Vitellogenesis
- Cell Adhesion
- Germinal Center Formation
- Intracellular Transport
- Cell Proliferation
- Endochondral Ossification
- Lung Development
- Pigmentation
- Vitamin A Transport
- Ossification
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Stra6
bosterbio.com/bosterbio-gene-info-cards/Stra6
References
PMID: 9203140 by Bouillet P., et al. Developmental expression pattern of Stra6, a retinoic acid-responsive gene encoding a new type of membrane protein.
PMID: 7644503 by Taneja R., et al. Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types.