Serine/threonine-protein kinase 36 (STK36)

Serine/threonine protein kinase that plays an important role in the sonic hedgehog (Shh) pathway by regulating the action of GLI transcription factors (PubMed:10806483). Controls the action of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the impact of SUFU and promoting their nuclear localization (PubMed:10806483).

GLI2 requires an extra purpose of STK36 to become transcriptionally active, but the enzyme does not have to have an active kinase catalytic site in order for this to occur (PubMed:10806483). Required for postnatal growth, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function (By similarity).