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- Table of Contents
1 Citations 5 Q&As
Facts about Stromal interaction molecule 1.
Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19249086, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:26322679, PubMed:25326555, PubMed:28219928).
Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domainname.Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1 (PubMed:16208375, PubMed:16537481). Involved in enamel formation (PubMed:24621671).
Human | |
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Gene Name: | STIM1 |
Uniprot: | Q13586 |
Entrez: | 6786 |
Belongs to: |
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No superfamily |
GOK; GOKD11S4896E; STIM1; stromal interaction molecule 1
Mass (kDA):
77.423 kDA
Human | |
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Location: | 11p15.4 |
Sequence: | 11; NC_000011.10 (3855664..4093210) |
Ubiquitously expressed in various human primary cells and tumor cell lines.
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Sarcoplasmic reticulum. Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane (PubMed:19249086, PubMed:16005298, PubMed:16208375, PubMed:18854159). Associated with the microtubule network at the growing distal tip of microtubules (PubMed:19632184). Colocalizes with ORAI1 at the ce
PMID: 8921403 by Parker N.J., et al. Molecular cloning of a novel human gene (D11S4896E) at chromosomal region 11p15.5.
PMID: 9377559 by Sabbioni S., et al. GOK: a gene at 11p15 involved in rhabdomyosarcoma and rhabdoid tumor development.
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