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STARD3 Antibodies
AND STARD3 ELISA kits, STARD3 Proteins
Many biological assays use antibodies to detect STARD3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with STARD3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop STARD3 antibodies...
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STARD3 Overview
Facts about StAR-related lipid transfer protein 3.
StAR-related lipid transfer protein 3 (STARD3)
Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum into endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts that the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263, PubMed:28377464).
Acts as a lipid transport protein that redirects sterol into the endosome at the cost of the cell membrane and favors membrane formation within endosomes (PubMed:28377464). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed:12070139, PubMed:19965586).
Gene Information
| Human | |
|---|---|
| Gene Name: | STARD3 |
| Uniprot: | Q14849 |
| Entrez: | 10948 |
Family
| Belongs to: |
|---|
| STARD3 family |
Alternative Names
CAB1; es64; Metastatic lymph node gene 64 protein; metastatic lymph node protein 64; MLN 64; MLN64FLJ41370; Protein CAB1; StARD3; StAR-related lipid transfer (START) domain containing 3; stAR-related lipid transfer protein 3; START domain containing 3; START domain-containing protein 3; steroidogenic acute regulatory protein related
Molecular Weight
Mass (kDA):
50.502 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q12 |
| Sequence: | 17; NC_000017.11 (39637080..39664201) |
Tissue Specificity
Expressed in retina.
Subcellular Localizations
Late endosome membrane; Multi-pass membrane protein. Localizes to contact sites between the endoplasmic reticulum and late endosomes: associates with the endoplasmic reticulum membrane via interaction with VAPA and VAPB (PubMed:24105263).
Diseases
- Malignant Neoplasms
- Neoplasms
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Carcinoma
- Stomach Neoplasms
- Adrenal Hyperplasia
- Lymphatic Metastasis
- Congenital Adrenal Hyperplasia
- Hyperplasia
- Esophageal Neoplasms
- Age Related Macular Degeneration
- Neoplasm Metastasis
Interacting Proteins
- GOPC
- VAPA
Pathways
- Transport
- Cholesterol Transport
- Lipid Transport
- Localization
- Proteolysis
- Intracellular Cholesterol Transport
- Translation
- Cholesterol Storage
- Cell Proliferation
- Dna Amplification
- Cholesterol Esterification
- Membrane Biogenesis
- Sterol Import
PTMs
- Cleavage
- Acetylation
Research Areas
- Breast Cancer
- Cancer
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/STARD3
bosterbio.com/bosterbio-gene-info-cards/STARD3
References
PMID: 7490069 by Tomasetto C.L., et al. Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17.
PMID: 9270027 by Akiyama N., et al. Isolation of a candidate gene, CAB1, for cholesterol transport to mitochondria from the c-ERBB-2 amplicon by a modified cDNA selection method.