ST8SIA4 Antibodies

AND ST8SIA4 ELISA kits, ST8SIA4 Proteins

Many biological assays use antibodies to detect ST8SIA4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ST8SIA4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ST8SIA4 antibodies...

We validate the specificity of these antibodies to ST8SIA4 by testing them on tissues known to express ST8SIA4 positively and negatively. Browse below to find the ST8SIA4 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ST8SIA4 Infographic by Boster Bio

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Anti-ST8SIA4 Antibody

Human

$405
Cat # A06267
100ul

ST8SIA4 Overview

Facts about CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase.

ST8SIA4 3D structure. Source: alphafold

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (ST8SIA4)

Catalyzes the polycondensation of alpha-2,8-linked sialic acid needed for the synthesis of polysialic acid (PSA), which can be present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells. .

Gene Information

Human
Gene Name:	ST8SIA4
Uniprot:	Q92187
Entrez:	7903

Family

Belongs to:

glycosyltransferase 29 family

Alternative Names

Alpha-2,8-sialyltransferase 8D; CMP-N-acetylneuraminate-poly-alpha-2,8-sialyl transferase; CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase; EC 2.4.99; EC 2.4.99.-; polysialyltransferase-1; PST1; PST1MGC61459; PSTMGC34450; sialyltransferase 8 (alpha-2, 8-polysialytransferase) D; Sialyltransferase 8D; Sialytransferase St8Sia IV; SIAT8D; SIAT8-D; ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4; ST8SIA4; ST8SIAIV; ST8SIA-IV

Molecular Weight

Mass (kDA):
41.295 kDA

Genomic Context


Human

Location:	5q21.1
Sequence:	5; NC_000005.10 (100806933..100903282, complement)

Tissue Specificity

Highly expressed in fetal brain, lung and kidney and in adult heart, spleen and thymus. Present to a lesser extent in adult brain, placenta, lung, large and small intestine and peripheral blood leukocytes.

Subcellular Localizations

Golgi apparatus membrane; Single-pass type II membrane protein.

Diseases

Tissue Adhesions
Neoplasms
Nervousness
Carcinoma
Leukemia
Monosomy
Learning Disorders
Neoplasm Metastasis
Teratocarcinoma
Malignant Neoplasm Of Lung
Parkinson Disease
Memory Disorders

Malignant Neoplasms
Pancreatic Neoplasm
Persistent Superficial Gastritis
Chimera Disorder
Malignant Neoplasm Of Pancreas
Cell Invasion
Chromosomal Deletion

Pathways

Cell Adhesion
Cell Migration
Glycosylation
Regeneration
Pathogenesis
Cell-cell Adhesion
Brain Development
Transport
Neuron Differentiation
Oxidative Phosphorylation
Cell Maturation

Drug Resistance
Dna Replication
Axon Guidance
Cell Growth
Interphase
Rna Interference

PTMs

Phosphorylation

Glycosylation

Ubiquitination

Research Areas

Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ST8SIA4

References

PMID: 7624364 by Nakayama J., et al. Expression cloning of a human polysialyltransferase that forms the polysialylated neural cell adhesion molecule present in embryonic brain.

PMID: 11279095 by Angata K., et al. Unique disulfide bond structures found in ST8Sia IV polysialyltransferase are required for its activity.