ST14 Antibodies

AND ST14 ELISA kits, ST14 Proteins

Many biological assays use antibodies to detect ST14, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ST14 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ST14 antibodies...

We validate the specificity of these antibodies to ST14 by testing them on tissues known to express ST14 positively and negatively. Browse below to find the ST14 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ST14 Infographic by Boster Bio

All ST14 Products

Product

Figures

Specificity

Applications

Price

Anti-Matriptase (K21) ST14 Antibody

Human, Mouse, Rat

IP, IF, IHC, WB

$405
Cat # A02614
100ul

ST14 (NM_021978) Human Over-expression Lysate

Human

$628
Cat # LS006768
100 µg

ST14 Overview

Facts about Suppressor of tumorigenicity 14 protein.

ST14 3D structure. Source: alphafold

Suppressor of tumorigenicity 14 protein (ST14)

Degrades extracellular matrix. Proposed to play a part in breast cancer invasion and metastasis.

Exhibits trypsin-like action as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing.

Gene Information

Human
Gene Name:	ST14
Uniprot:	Q9Y5Y6
Entrez:	6768

Family

Belongs to:

peptidase S1 family

Alternative Names

EC 3.4.21; Epithin; HAI; Matriptase; Membrane-type serine protease 1; MTSP1; MT-SP1EC 3.4.21.109; prostamin; PRSS14; Serine protease 14; Serine protease TADG-15; SNC19; SNC19MTSP1; ST14; suppression of tumorigenicity 14 (colon carcinoma); suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin); suppressor of tumorigenicity 14 protein; TADG15; TADG-15; TMPRSS14; tumor associated differentially expressed gene 15 protein; Tumor-associated differentially-expressed gene 15 protein

Molecular Weight

Mass (kDA):
94.77 kDA

Genomic Context


Human

Location:	11q24.3
Sequence:	11; NC_000011.10 (130159782..130210362)

Subcellular Localizations

Membrane; Single-pass type II membrane protein.

Diseases

Hemophilia A
Malignant Neoplasms
Neoplasms
Neoplasm Metastasis
Cell Invasion
Carcinoma
Variable Number Tandem Repeat
Sex Chromosome Aberrations
Fragile X Syndrome
Malignant Neoplasm Of Breast
Mammary Neoplasms
Tissue Adhesions

Neoplasm Invasiveness
Malignant Paraganglionic Neoplasm
Ichthyoses
Cell Transformation, Neoplastic
Hemorrhage
Ovarian Neoplasm
Hypotrichosis

Pathways

Coagulation
Cell Migration
Proteolysis
Cell Adhesion
Cell Proliferation
Localization
Zymogen Activation
Transport
Epithelial To Mesenchymal Transition
Pathogenesis
Fertilization
Immune Response
Virulence

Cell Cycle
Wound Healing
Metaphase
Methylation
Tissue Remodeling
Transposition
Hair Follicle Development

PTMs

Cleavage
Phosphorylation
Glycosylation

Methylation
Demethylation
Biotinylation

Reduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ST14

References

PMID: 10373424 by Lin C.Y., et al. Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity.

PMID: 10500122 by Takeuchi T., et al. Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue.