Serine/arginine-rich splicing factor 2 (SRSF2)

Necessary for the splicing of pre-mRNA.

It is needed for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly.

It also is needed for ATP-dependent interactions of both U1 and U2 snRNPs with pre- mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding elements, U1 snRNP and U2AF.