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- Table of Contents
Facts about Sushi repeat-containing protein SRPX2.
Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic action of HGF.
Human | |
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Gene Name: | SRPX2 |
Uniprot: | O60687 |
Entrez: | 27286 |
Belongs to: |
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No superfamily |
BPP; CBPS; RESDX; SRPULPMGX; sushi repeat-containing protein SRPX2; sushi-repeat containing protein, X-linked 2; sushi-repeat protein up-regulated in leukemia; sushi-repeat-containing protein, X-linked 2
Mass (kDA):
52.972 kDA
Human | |
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Location: | Xq22.1 |
Sequence: | X; NC_000023.11 (100644199..100675788) |
Expressed in neurons of the rolandic area of the brain (at protein level). Highly expressed in the brain, placenta, lung, trachea, uterus, adrenal gland, heart, ovary and placenta. Weakly expressed in the peripheral blood, brain and bone marrow. Expressed in numerous cancer cell lines and in gastrointestinal cancer cells. Higher levels found in colorectal cancers than in normal colonic mucosa.
Secreted. Cytoplasm. Cell surface. Cell junction, synapse.
PMID: 9864177 by Kurosawa H., et al. Two candidate downstream target genes for E2A-HLF.
PMID: 16497722 by Roll P., et al. SRPX2 mutations in disorders of language cortex and cognition.