Sterol regulatory element-binding protein 2 (SREBF2)

Transcriptional activator necessary for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity).

Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') located in the flanking region of the LDRL and HMG-CoA synthase genes. .