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- Table of Contents
Facts about Sterol regulatory element-binding protein 2.
Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') located in the flanking region of the LDRL and HMG-CoA synthase genes. .
Human | |
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Gene Name: | SREBF2 |
Uniprot: | Q12772 |
Entrez: | 6721 |
Belongs to: |
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SREBP family |
bHLhd2; bHLHd2sterol regulatory element-binding protein 2; Class D basic helix-loop-helix protein 2; SREBF2; SREBP2; SREBP2SREBP-2; sterol regulatory element binding transcription factor 2; Sterol regulatory element-binding transcription factor 2
Mass (kDA):
123.688 kDA
Human | |
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Location: | 22q13.2 |
Sequence: | 22; NC_000022.11 (41833105..41907308) |
Ubiquitously expressed in adult and fetal tissues.
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.; [Processed sterol regulatory element-binding protein 2]: Nucleus.
PMID: 7903453 by Hua X., et al. SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.
PMID: 8402897 by Yokoyama C., et al. SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene.