Steroid receptor RNA activator 1 (SRA1)

Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the regulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand- dependently through the steroid-binding domain (AF-2).

Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.