Leukosialin Antibodies

Leukosialin (SPN)

Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking into lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity).

Negatively regulates Th2 cell differentiation and predisposes the distinction of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells through T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228).

Gene Information

Human
Gene Name:	SPN
Uniprot:	P16150
Entrez:	6693

Family

Belongs to:
No superfamily

Alternative Names

CD43 antigen; CD43; CD43); Galactoglycoprotein; GALGP; GPL115; Leukocyte sialoglycoprotein; Leukosialin; LSN; Ly-48; sialophorin (gpL115, leukosialin, CD43); Sialophorin; SPN

Molecular Weight

Mass (kDA):
40.322 kDA

Genomic Context

Human
Location:	16p11.2
Sequence:	16; NC_000016.10 (29662950..29670876)

Tissue Specificity

Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.

Subcellular Localizations

Membrane; Single-pass type I membrane protein. Cell projection, microvillus. Cell projection, uropodium. Localizes to the uropodium and microvilli via its interaction with ERM proteins (EZR, RDX and MSN).; [CD43 cytoplasmic tail]: Nucleus. Nucleus, PML body.

Diseases

• Solitary Pulmonary Nodule
• Malignant Paraganglionic Neoplasm
• Neoplasms
• Malignant Neoplasms
• Lung Neoplasms
• Tissue Adhesions
• Malignant Neoplasm Of Lung
• Carcinoma
• Neoplasm Metastasis
• Pneumonia
• Nervousness
• Adenocarcinoma
• Disease Of Adrenal Medulla

• Inflammation
• Pancreatic Neoplasm
• Cholera
• Pain
• Infective Disorder
• Tuberculosis
• Tuberculosis, Pulmonary

Pathways

• Localization
• Reflex
• Innervation
• Transport
• Cell Activation
• Micturition
• T Cell Activation
• Pathogenesis
• Cell Development
• Secretion
• Cell Proliferation
• Glycosylation
• Cell Adhesion

• Cell Differentiation
• Virulence
• Cell Cycle
• Cell Division
• Cell Growth
• B Cell Differentiation
• Immune Response

PTMs

• Glycosylation
• Phosphorylation
• Acetylation
• Biotinylation
• Cleavage

• Methylation
• Dephosphorylation
• Phosphorothioation
• Prenylation
• Iodination

Research Areas

• Immunology

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPN

Boster Bio - Best Uses Of The SPN Marker

Steven Boster, aka "the guy who turns science in the lavatory," is one of the founders of the company. The company, which started in 1993, has hundreds of primary antibodies and various products for IHC. By the late 1990s, Boster had become one of China's largest antibody catalog companies. Boster developed proprietary trade secrets and created PicoKine(tm), a platform for developing high-sensitivity ELISA kits.

Boster's gene infographics

The infographics on Boster's gene website contain basic information on each gene. They cover all genes that exist in humans and mice. A search bar allows you to find the gene that interests you. Each of the gene's basic characteristics is highlighted in a color. Boster's infographics have many helpful features to help you learn more about a particular gene. You may even be surprised at what you learn!