Leukosialin (SPN)

Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking into lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity).

Negatively regulates Th2 cell differentiation and predisposes the distinction of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells through T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228).