SPEG Antibodies

AND SPEG ELISA kits, SPEG Proteins

Many biological assays use antibodies to detect SPEG, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SPEG in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SPEG antibodies...

We validate the specificity of these antibodies to SPEG by testing them on tissues known to express SPEG positively and negatively. Browse below to find the SPEG antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SPEG Infographic by Boster Bio

All SPEG Products

Product

Figures

Specificity

Applications

Price

Anti-SPEG Antibody

Human, Mouse, Rat

IHC

$380
Cat # A04825
100ul

SPEG Overview

Facts about Striated muscle preferentially expressed protein kinase.

Striated muscle preferentially expressed protein kinase (SPEG)

Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. .

Gene Information

Human
Gene Name:	SPEG
Uniprot:	Q15772
Entrez:	10290

Family

Belongs to:

protein kinase superfamily

Alternative Names

aortic preferentially expressed gene 1; Aortic preferentially expressed protein 1; APEG1; BPEG; EC 2.7.11; EC 2.7.11.1; KIAA1297APEG-1; MGC12676; nuclear protein, marker for differentiated aortic smooth muscle anddown-regulated with vascular injury; SPEG complex locus; SPEGalpha; SPEGbeta; striated muscle preferentially expressed protein kinase

Molecular Weight

Mass (kDA):
354.289 kDA

Genomic Context


Human

Location:	2q35
Sequence:	2; NC_000002.12 (219434215..219493629)

Tissue Specificity

Isoform 1 is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 is predominantly expressed in the aorta. Isoform 3 appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC in vivo. In response to vascular injuries ASMC dedifferentiate and change from a quiescent and contractile phenotype to a proliferative and synthetic phenotype. This proliferation of vascular smooth muscle cells is one of the most prominent features of atherosclerosis.

Subcellular Localizations

[Isoform 3]: Nucleus.

Diseases

Streptococcal Infections
Infective Disorder
Toxic Shock Syndrome
Peripheral Circulatory Failure
Pharyngitis
Fasciitis
Necrotizing Fasciitis
Toxic Shock Syndrome Streptococcal
Septic Shock
Tissue Adhesions
Plant Diseases
Hemorrhage
Surgical Wound Infection

Vascular System Injuries
Nervousness
Cross Infection
Cardiomyopathy, Dilated
Cardiomyopathies
Arteriosclerosis
Skin Diseases, Bacterial

Interacting Proteins

PRMT1

Pathways

Virulence
Pathogenesis
Cell Adhesion
Photosynthesis
Hypersensitivity
Glycosylation
Transport
Gene Silencing
Electron Transport
Fertilization
Protein Glycosylation
Host-pathogen Interaction
Seed Development

System Development
Axon Guidance
Nitrogen Fixation
Response To Cold
Gravitropism
Central Nervous System Development
Myofibril Assembly

PTMs

Glycosylation
Acetylation

Oxidation
Iodination

Research Areas

Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPEG

References

PMID: 8663449 by Hsieh C.-M., et al. APEG-1, a novel gene preferentially expressed in aortic smooth muscle cells, is down-regulated by vascular injury.

PMID: 16545539 by Tam J.L.Y., et al. The human desmin locus: gene organization and LCR-mediated transcriptional control.