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SPAG8 Antibodies
AND SPAG8 ELISA kits, SPAG8 Proteins
Many biological assays use antibodies to detect SPAG8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SPAG8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SPAG8 antibodies...
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SPAG8 Overview
Facts about Sperm-associated antigen 8.
Sperm-associated antigen 8 (SPAG8)
Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity).
Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is needed for entry into mitosis (PubMed:19548270). May play a role in fertility and microtubule formation through interaction with RANBP9 (PubMed:10500252).
Gene Information
| Human | |
|---|---|
| Gene Name: | SPAG8 |
| Uniprot: | Q99932 |
| Entrez: | 26206 |
Family
| Belongs to: |
|---|
| SPAG8 family |
Alternative Names
BS-84; HSD-1MGC26201; hSMP-1; SMP1; SMP-1; SPAG3; sperm associated antigen 8; Sperm membrane protein 1; Sperm membrane protein BS-84; sperm-associated antigen 8
Molecular Weight
Mass (kDA):
51.139 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9p13.3 |
| Sequence: | 9; NC_000009.12 (35807785..35812272, complement) |
Tissue Specificity
Expressed in testis (germ cells), but not in liver, kidney, prostate and small intestine.
Subcellular Localizations
Cytoplasm. Nucleus. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton, spindle. In mature sperm cells, detected in the acrosomal region of the head and in the middle piece of the tail (By similarity). Localized to the nucleus and cytoplasm of spermatocytes and round spermatids while, in elongating spermatids, expressed in the cytoplasm but not in the nucleus (By similarity). During the cell cycle, localized on the microtubule-organizing center (MTOC) during prophase. In metaphase, extends along spindle microtubules
Diseases
- Infertility
- Malignant Neoplasms
- Neoplasms
- Cholangiocarcinoma
- Sclerosis
- Primary Lateral Sclerosis
- Melanoma
- Malignant Neoplasm Of Breast
- Uterine Cervical Neoplasm
- Dementia
- Hemophagocytic Lymphohistiocytosis, Familial, 5
- Glioma
- Endometrial Polyp
Interacting Proteins
- CSTF2
- DTX2
- PITX1
Pathways
- Spermatogenesis
- Cell Differentiation
- Immune Response
- Metaphase
- Localization
- Regulation Of Cell Cycle
- Fertilization
- Humoral Immune Response
- Anaphase
- Cytokinesis
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPAG8
bosterbio.com/bosterbio-gene-info-cards/SPAG8
References
PMID: 8788182 by Liu Q.-Y., et al. Expression and characterization of a novel human sperm membrane protein.
PMID: 10500252 by Wang H., et al. Assignment of chromosomal locus and evidence for alternatively spliced mRNAs of a human sperm membrane protein (hSMP-1).