Transcription factor Sp4 Antibodies

Transcription factor Sp4 (SP4)

Binds to GT and GC boxes promoters elements. Probable transcriptional activator.

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Gene Information

Human
Gene Name:	SP4
Uniprot:	Q02446
Entrez:	6671

Family

Belongs to:
Sp1 C2H2-type zinc-finger protein family

Alternative Names

Transcription factor Sp4

Molecular Weight

Mass (kDA):
81.985 kDA

Genomic Context

Human
Location:	7p15.3
Sequence:	7; NC_000007.14 (21428083..21514822)

Tissue Specificity

Abundant in brain.

Subcellular Localizations

Nucleus.

Interacting Proteins

• ADAM15
• CIB3
• COL8A1
• LMO3
• NRF1

• POU2F1
• PRR20C
• PRR20D

PTMs

• Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SP4

Boster Bio - Best Uses Of The SP4 Marker

Boster Bio is a supplement that increases immunity and protects against a variety of diseases. This article reviews the product as well as the SP4 marker and what it can do for you. It is important to remember that this product isn't for everyone but it could benefit you when you're a scientist. The product's credits to scientists will help you get more understanding of what the SP4 Marker can do and how you can use it to your advantage.

Boster Bio

The Boster Bio SP4 Marker will do the job, regardless of whether you need to assay for a specific species or application, or even a sample. The SP4 marker is a highly sensitive antibody that reacts with human and mouse cells. The SP4 antibody can be stored at -20degC for six months. The SP4 antibody is tested by Boster Bio. Boster Bio sells the SP4 marker.

Sp4 Marker Anti-Transcription Factor

The SP4 transcription factor binds to GC promoter areas of many genes. It also functions via binding sites that are adjacent as did its predecessor SP1. Boster Bio validates all its antibodies prior to their sale. SP4 is associated with hermansky-pudlak disease, digenic disease and RNA polymerase II-specific transcription.

The NMDA receptors regulate Sp4 which in turn activates the signaling pathways PP1-PP2A. The results of the Sp4 marker offer new insights into the mechanisms involved in neuronal activity that in turn affects the gene expression program in the nervous system. The SP4 gene is also essential in the development and function of the nervous system.

The SP4 antigen is found in a variety of tissues that include the skin, brain and heart. It is expressed in the same amount in CG neurons and can be restored in heterologous cells. It works in the same manner as wild-type Sp4 and activates the TrkC luciferase reporter. Furthermore, its expression is similar to wild-type Sp4. The SP4 S770 phosphorylation didn't affect overall SP4 immunoreactivity. This suggests that it is caused by changes in upstream signaling pathways.

The SP4 marker is highly immunoreactive and may detect the phosphorylated and total SP4 protein. It also displays similar patterns of expression in tissues as SP4 total antibody. The phosphosp4 antibodies cannot bind to Sp4 Peptides in phosphatase lysates. The phospho-Sp4 antigen has an extremely high degree of specificity against Sp4's S770 residue. The phosphosp4 antibody is useful in studies that require quantitative measures to determine SP4 phosphorylation.

Calcium (Ca2+) Signaling is activated when sodium levels in extracellular tissues are decreased. This mechanism regulates the neuronal connectivity and plasticity and also maturation. At rest the influx of Ca2+ promotes Sp4 degradation in neurons. Soce could be triggered by the decrease in potassium levels in extracellular. It could be another mechanism for controlling the expression of neuronal genes.

Benefits of using the SP4 Marker

The SP4 marker now supports Intel Optane DC memory. These new memory systems allow SAP workloads to benefit greatly from persistent memory. They also offer shorter start times and greater stability for the system. The SP4 Marker currently supports configurations that include up to 12 TB of NVDIMMs. The latest SUSE HANA software version also includes XFS file systems, which allows it to run in the DAX mode.