Transcription factor Sp3 Antibodies

AND SP3 ELISA kits, Transcription factor Sp3 Proteins

Many biological assays use antibodies to detect Transcription factor Sp3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transcription factor Sp3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transcription factor Sp3 antibodies...

We validate the specificity of these antibodies to Transcription factor Sp3 by testing them on tissues known to express SP3 positively and negatively. Browse below to find the SP3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SP3 Infographic by Boster Bio

All SP3 Products

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Specificity

Applications

Price

Anti-SP3 Antibody Picoband®

1 Q&As

Human, Mouse, Rat

IHC, WB

$370
Cat # PB9508
100 μg/vial

SP3 (NM_003111) Human Over-expression Lysate

Human

$960
Cat # LS006670
100 µg

SP3 Overview

Facts about Transcription factor Sp3.

SP3 3D structure. Source: alphafold

Transcription factor Sp3 (SP3)

Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements.

Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone- induction and house-keeping.

Gene Information

Human
Gene Name:	SP3
Uniprot:	Q02447
Entrez:	6670

Family

Belongs to:

Sp1 C2H2-type zinc-finger protein family

Alternative Names

DKFZp686O1631; GC-binding transcription factor Sp3; Sp3 transcription factor; Sp3; specificity protein 3; SPR2; SPR-2; transcription factor Sp3

Molecular Weight

Mass (kDA):
81.925 kDA

Genomic Context


Human

Location:	2q31.1
Sequence:	2; NC_000002.12 (173900775..173965702, complement)

Tissue Specificity

Ubiquitously expressed.

Subcellular Localizations

Nucleus. Nucleus, PML body. Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies.

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Malignant Neoplasm Of Breast
Mammary Neoplasms
Traditional Serrated Adenoma
Liver Carcinoma
Tumor Angiogenesis
Leukemia
Neoplasm Metastasis
Cell Transformation, Neoplastic
Adenocarcinoma
Neuroblastoma

Inflammation
Malignant Tumor Of Colon
Malignant Paraganglionic Neoplasm
Endometrial Polyp
Fibrosis
Retinoblastoma
Nervousness

Interacting Proteins

ESR1

Pathways

Methylation
Translation
Cell Cycle
Pathogenesis
Angiogenesis
Cell Proliferation
Cell Growth
Secretion
Rna Interference
Cell Differentiation
Localization
Dna Methylation
Transport

Histone Acetylation
Regulation Of Gene Expression
Cell Death
Demethylation
Gene Silencing
Cell Cycle Arrest
Dna Replication

PTMs

Phosphorylation
Methylation
Acetylation
Cleavage
Oxidation
Dephosphorylation
Demethylation
Deacetylation
Sumoylation
Amination

Reduction
Amidation
Glycosylation
Carboxylation
Hydroxylation
Deamination
Decarboxylation
Ubiquitination
Formylation
Glutathionylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SP3

References

PMID: 12297010 by Hernandez E.M., et al. AUA as a translation initiation site in vitro for the human transcription factor Sp3.

PMID: 15474306 by Moran K.M., et al. Human transcription factor Sp3: genomic structure, identification of a processed pseudogene, and transcript analysis.