This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
SP100 Antibodies
AND SP100 ELISA kits, SP100 Proteins
Many biological assays use antibodies to detect SP100, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SP100 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SP100 antibodies...
Previous: CBLIF
Next: SPAG1
SP100 Infographic by Boster Bio
All SP100 Products
Product
Figures
Specificity
Applications
Price
SP100 Overview
Facts about Nuclear autoantigen Sp-100.
Nuclear autoantigen Sp-100 (SP100)
Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a high number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 based on PubMed:11909962.
Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA based on PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion.
Gene Information
| Human | |
|---|---|
| Gene Name: | SP100 |
| Uniprot: | P23497 |
| Entrez: | 6672 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
DKFZp686E07254; FLJ00340; FLJ34579; lysp100b; nuclear antigen Sp100; nuclear autoantigen Sp-100; Nuclear dot-associated Sp100 protein; SP100 nuclear antigen; SP100-HMG nuclear autoantigen; Speckled 100 kDa
Molecular Weight
Mass (kDA):
100.417 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q37.1 |
| Sequence: | 2; NC_000002.12 (230416156..230545606) |
Tissue Specificity
Widely expressed. Sp100-B is expressed only in spleen, tonsil, thymus, mature B-cell line and some T-cell line, but not in brain, liver, muscle or non-lymphoid cell lines.
Subcellular Localizations
Nucleus. Nucleus, PML body. Cytoplasm. Differences in the subnuclear localization of the different isoforms seem to exist and may also be cell cycle- and interferon-dependent. Accumulates in the cytoplasm upon FAS activation.; [Isoform Sp100-C]: Nucleus. Forms a reticulate or track-like nuclear pattern with denser concentrations at the nuclear lamina and surrounding the nucleoli, a pattern reminiscent of heterochromatin-rich regions according to PubMed:11313457.
Diseases
- Leukemia
- Acute Promyelocytic Leukemia
- Biliary Cirrhosis
- Primary Biliary Cirrhosis
- Liver Cirrhosis
- Autoimmune Reaction
- Virus Diseases
- Cytomegalovirus Infections
- Infective Disorder
- Liver Diseases
- Neoplasms
- Autoimmune Diseases
Interacting Proteins
- ACTN2
- CASP8AP2
- CBX5
- DNMT3A
- DYRK2
- ETS1
- GIPC2
- L3MBTL3
- RTP5
- SUMO1
Pathways
- Localization
- Pathogenesis
- Viral Replication
- Dna Replication
- Cell Cycle
- Immune Response
- Conjugation
- Interphase
- Dna Repair
- Mitosis
- Rna Interference
- Cell Proliferation
- Senescence
PTMs
- Sumoylation
- Phosphorylation
- Methylation
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SP100
bosterbio.com/bosterbio-gene-info-cards/SP100
References
PMID: 2258622 by Szostecki C., et al. Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis.
PMID: 8695863 by Dent A.L., et al. LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies.