SORBS1 Antibodies

AND SORBS1 ELISA kits, SORBS1 Proteins

Many biological assays use antibodies to detect SORBS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SORBS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SORBS1 antibodies...

We validate the specificity of these antibodies to SORBS1 by testing them on tissues known to express SORBS1 positively and negatively. Browse below to find the SORBS1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SORBS1 Infographic by Boster Bio

All SORBS1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-SORBS1 Picoband® Antibody

Human

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A04426-3
100 μg/vial

SORBS1 (NM_001034955) Human Recombinant Protein

$1062
Cat # PROTQ9BX66
20 µg

SORBS1 (NM_001034955) Human Over-expression Lysate

Human

$960
Cat # LS010580
100 µg

SORBS1 Overview

Facts about Sorbin and SH3 domain-containing protein 1.

SORBS1 3D structure. Source: alphafold

Sorbin and SH3 domain-containing protein 1 (SORBS1)

Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport.

Involved in formation of actin stress fibers and focal adhesions (By similarity). .

Gene Information

Human
Gene Name:	SORBS1
Uniprot:	Q9BX66
Entrez:	10580

Family

Belongs to:

No superfamily

Alternative Names

c-Cbl associated protein; c-Cbl-associated protein; DKFZp451C066; DKFZp586P1422; Fas-ligand associated factor 2; FLAF2; KIAA0894; KIAA1296CAPSH3D5SH3P12FLJ12406; Ponsin; R85FL; SH3 domain protein 5; SH3-domain protein 5 (ponsin); sh3p12; SORB1; sorbin and SH3 domain containing 1; sorbin and SH3 domain-containing protein 1

Molecular Weight

Mass (kDA):
142.513 kDA

Genomic Context


Human

Location:	10q24.1
Sequence:	10; NC_000010.11 (95311773..95561439, complement)

Tissue Specificity

Detected in skeletal muscle (at protein level). Widely expressed with highest levels in heart and skeletal muscle.

Subcellular Localizations

Cell junction, adherens junction. Cell membrane. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus. Nucleus matrix. Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation.

Diseases

Insulin Resistance
Obesity
Malignant Neoplasms
Diabetes Mellitus
Polycystic Ovary Syndrome
Neoplasms
Carcinoma
Diabetes Mellitus, Non-insulin-dependent
Inflammation
Teratoma
Embryonal Carcinoma
Melanoma

Infarction
Malignant Neoplasm Of Breast
Seminoma
Neoplasms, Germ Cell And Embryonal
Brain Infarction
Cerebrovascular Accident

Interacting Proteins

ABL1
ATXN7
Dnm2
HTT
INPPL1

PAK2

Pathways

Methylation
Transport
Cell Proliferation
Protein Splicing
Aging
Dna Methylation
Dna Repair
Plasma Cell Differentiation
Localization
Cell Differentiation

Androgen Secretion
Fatty Acid Oxidation
Pathogenesis
Glucose Transport
Secretion

PTMs

Methylation
Phosphorylation

Demethylation
Dephosphorylation

Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SORBS1

References

PMID: 11374898 by Lin W.-H., et al. Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B.

PMID: 11371513 by Lebre A.-S., et al. Ataxin-7 interacts with a Cbl-associated protein that it recruits into neuronal intranuclear inclusions.