SOCS5 Antibodies

Suppressor of cytokine signaling 5 (SOCS5)

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Inhibits for example EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway that promotes differentiation to the Th2 phenotype.

Gene Information

Human
Gene Name:	SOCS5
Uniprot:	O75159
Entrez:	9655

Family

Belongs to:
No superfamily

Alternative Names

CIS6; CIS6Cytokine-inducible SH2 protein 6; CISH5; CISH6; CISH6CIS-6; KIAA0671Cytokine-inducible SH2-containing protein 5; SOCS5; SOCS-5; SOCS-5CISH5; suppressor of cytokine signaling 5

Molecular Weight

Mass (kDA):
61.246 kDA

Genomic Context

Human
Location:	2p21
Sequence:	2; NC_000002.12 (46698960..46763129)

Diseases

• Inflammation
• Janiceps
• Neoplasms
• Asthma
• Malignant Neoplasms
• Dermatitis, Atopic
• Dermatitis
• Immune System Diseases
• Uveitis
• Cell Transformation, Neoplastic
• Bronchial Hyperreactivity
• Autoimmune Diseases
• Allergic Conjunctivitis

• Eosinophilia
• Conjunctivitis
• Autoimmune Reaction
• Neoplasm Metastasis
• Respiration Disorders
• Carcinoma
• Allergic Asthma

Interacting Proteins

• MET

Pathways

• Immune Response
• Pathogenesis
• Cell Differentiation
• Cell Activation
• Cell Proliferation
• Sensitization
• T Cell Differentiation
• Skin Morphogenesis
• Cell Migration
• Cell Development
• T Cell Activation
• Regulation Of T Cell Differentiation
• Dna Demethylation

• Hypersensitivity
• Mast Cell Activation
• Demethylation
• Endothelial Cell Migration
• Translation
• Cell Death
• Regulation Of Angiogenesis

PTMs

• Phosphorylation

• Demethylation

• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SOCS5

Boster Bio: Best Uses Of The SOCS5 Marker

The SOCS5 gene-marker (formerly known as SMART5 gene) is a key genetic factor in autoimmune disorders. Researchers are discovering that it can help to target the disease-causing gene. Although scientists are not aware of this gene, it is being used more widely to combat Alzheimer's and other forms. The SOCS5 gene-marker is used in many applications, including drug development, animal health and genetics. This marker has been used to produce a series of high affinity primary antibodies.

History of Steven Boster

You can learn a lot about Steven Boster's life history if you are interested. Boster's family is one of the most interesting facts. He loved them more than anything else. Boster was a dedicated father and husband. He also had a lower-register singing ability when performing in front of his family. He also had a passion to auto racing. He was often first to respond to a 911 call at 2 AM or when his car crashed at below freezing. He was generous with friends and treated them like family.

Steve Boster died June 6, 20,22. He was born in Joliet, Illinois and was a successful retail sales manager for many years. He was also a Concordia Hall member in Staunton, Virginia. His surviving family members include two daughters, Natosha Peck and Crystal Boster, six grandchildren, and 4 brothers, Jack Boster, Sandra Blanton, and Lisa Milton. Many nieces & nephews survive him in addition to his spouse.

Boster's high-affinity primary antibodies

Boster primary antibodies are highly specific. They bind to target proteins with high affinity. These antibodies are useful in many areas of research, including drug discovery or diagnostics. Boster uses the SOCS5 marker to differentiate its antibodies from those of competitors. The company has over 40,000 catalogue antibodies and specialized protocol reagents.

Capralogics, which produces monoclonal antibody for rabbits or goats, is an example company. Capricorn Products, a biotechnology firm, also produces antibodies and immunoassays in a variety of research areas. Other companies, such as Cedarlane Laboratories, produce polyclonal and monoclonal antibodies and ELISA kits.

Boster's high-affinity, primary antibody using SOCS5 markers is also marked. This reagent is highly specific. Boster is able to create a broad range monoclonal antibody for immunoassays because of the high affinity of these reagents. It's tempting to use monoclonal immuneassays. However it is better that you use polyclonal antibodies for diagnostics.

Traditional chromogenic MIHC relies only on antibodies that have been raised from different species, or isotypes, of the same target. Boster's high affinity primary antibodies are excellent candidates for mIHC applications. The SOCS5 marker is also a good candidate. This marker allows researchers distinguish between multiple markers by using fewer tissue sections. A counterstain is useful in the localization the primary antibody.

Another company that offers innovative IHC products is BioCare Medical, which manufactures 20,000+ monoclonal and polyclonal antibodies. They also offer a Protein L marker that binds many different types immunoglobulins. Another company that specializes in epigenetics and biotechnology provides over 4,000 research products, including antibodies and detection systems.

Primary antibodies and secondary antibodies are the main ingredients in immunoassays. These antibodies recognize an antigen by binding it. Typical immunoassays include Western Blotting, immunohistochemistry, and immunofluorescence. Another type of immunoassay, ELISA (Enzyme-Linked Immunosorbent assay), is ELISA. Another type is flow Cytometry, which measures the number of certain types cells.