This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Sorting nexin-3.
Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity). Plays a role in protein transport between cellular compartments.
Human | |
---|---|
Gene Name: | SNX3 |
Uniprot: | O60493 |
Entrez: | 8724 |
Belongs to: |
---|
sorting nexin family |
Grd19; MCOPS8; MGC17570; Protein SDP3; SDP3; sorting nexin 3; sorting nexin 3A; sorting nexin-3
Mass (kDA):
18.762 kDA
Human | |
---|---|
Location: | 6q21 |
Sequence: | 6; NC_000006.12 (108211222..108261040, complement) |
Early endosome. Cytoplasmic vesicle, phagosome. Colocalizes to clathrin-coated endosomal vesicles morphologically distinct from retromer-decorated non-branched endosomal tubule structures (PubMed:21725319) Colocalizes with EEA1 on nascent phagosomes in dendritic cells but competes with EEA1 for binding to phagosomal membrane (PubMed:23237080). In the case of Salmonella enterica infection localizes to Salmonella-containing vacuoles (SCVs) from which SNX3-containing tubules form 30-60 min after infection (PubMed:20482551).
PMID: 9819414 by Haft C.R., et al. Identification of a family of sorting nexin molecules and characterization of their association with receptors.
PMID: 11433298 by Xu Y., et al. SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P.