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Alpha-1-syntrophin Antibodies
AND SNTA1 ELISA kits, Alpha-1-syntrophin Proteins
Many biological assays use antibodies to detect Alpha-1-syntrophin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Alpha-1-syntrophin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Alpha-1-syntrophin antibodies...
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SNTA1 Infographic by Boster Bio
All SNTA1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
Flow Cytometry, IF, IHC, ICC, WB
$405
Cat # A05370
100ul
Cat # A05370
100ul
Dog, Human, Monkey, Mouse, Rat
Flow Cytometry, IF, WB
$523
Cat # M05370
100 µl
Cat # M05370
100 µl
Human, Mouse
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M05370-1
100 μl/vial
Cat # M05370-1
100 μl/vial
SNTA1 Overview
Facts about Alpha-1-syntrophin.
Alpha-1-syntrophin (SNTA1)
Adapter protein that binds to and probably organizes the subcellular localization of an assortment of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix through the dystrophin glycoprotein complex.
Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5- bisphosphate (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | SNTA1 |
| Uniprot: | Q13424 |
| Entrez: | 6640 |
Family
| Belongs to: |
|---|
| syntrophin family |
Alternative Names
59 kDa dystrophin-associated protein A1 acidic component 1; dJ1187J4.5; LQT12; Pro-TGF-alpha cytoplasmic domain-interacting protein 1; SNT1alpha-1-syntrophin; syntrophin, alpha 1 (dystrophin-associated protein A1, 59kD, acidic component); syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component); syntrophin-1; TACIP1acidic alpha 1 syntrophin
Molecular Weight
Mass (kDA):
53.895 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q11.21 |
| Sequence: | 20; NC_000020.11 (33407957..33443853, complement) |
Tissue Specificity
High expression in skeletal muscle and heart. Low expression in brain, pancreas, liver, kidney and lung. Not detected in placenta.
Subcellular Localizations
Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cell junction. Cytoplasm, cytoskeleton. In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions.
Diseases
- Long Qt Syndrome
- Cardiac Death
- Cardiac Arrhythmia
- Neoplasms
- Sudden Cardiac Death
- Carcinoma
- Malignant Neoplasms
- Sudden Death
- Malignant Squamous Cell Neoplasm
- Cardiomyopathies
- Hypertrophy
- Neoplasm Metastasis
- Tongue Neoplasms
Interacting Proteins
- ABCA1
- ADRA1D
- Mapk12
Pathways
- Pathogenesis
- Fibril Organization
- Muscle Hypertrophy
- Cell Cycle
- Collagen Fibril Organization
- Extracellular Matrix Organization
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SNTA1
bosterbio.com/bosterbio-gene-info-cards/SNTA1
References
PMID: 8576247 by Ahn A.H., et al. The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives.
PMID: 8612778 by Castello A., et al. Characterization of the dystrophin-syntrophin interaction using the two-hybrid system in yeast.